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    Henoch-Schonlein purpura in mesothelioma

    Access Status
    Open access via publisher
    Authors
    Joshi, S.
    Pillai, S.
    Chakera, Aron
    Lee, Y.
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Joshi, S. and Pillai, S. and Chakera, A. and Lee, Y. 2014. Henoch-Schonlein purpura in mesothelioma. Respirology Case Reports. 2 (4): pp. 138-140.
    Source Title
    Respirology Case Reports
    DOI
    10.1002/rcr2.78
    ISSN
    2051-3380
    School
    Curtin Medical School
    URI
    http://hdl.handle.net/20.500.11937/52465
    Collection
    • Curtin Research Publications
    Abstract

    © 2014 The Authors.Henoch-Schonlein purpura (HSP) is primarily a childhood immunoglobulin A (IgA)-mediated illness. When adults are affected, malignancy can be associated. We present a rare case of HSP in a 75-year-old man with malignant pleural mesothelioma. He presented with episodes of dizziness and subsequently developed non-palpable purpura across his legs, arthralgia, hematuria, proteinuria, and acute renal impairment. HSP was diagnosed based on clinical and histological findings on biopsy specimens from the skin and kidney that showed a leukocytoclastic vasculitis and mesangioproliferative glomerulonephritis with IgA deposits, respectively. He was treated with high-dose oral steroids with resolution of the skin and renal manifestations of the disease. HSP is rare in adults but has been linked to cancers. This is the first report of HSP in a patient with known malignant pleural mesothelioma.

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