Calcium ions as bioinspired triggers to reversibly control the coil-to-helix transition in peptide-polymer conjugates

Kühnle, R.; Gebauer, Denis; Börner, H.

doi:10.1039/c1sm05625e

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Authors

Kühnle, R.

Gebauer, Denis

Börner, H.

Date

2011

Type

Journal Article

Metadata

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Citation

Kühnle, R. and Gebauer, D. and Börner, H. 2011. Calcium ions as bioinspired triggers to reversibly control the coil-to-helix transition in peptide-polymer conjugates. Soft Matter. 7 (20): pp. 9616-9619.

Source Title

Soft Matter

DOI

10.1039/c1sm05625e

ISSN

1744-683X

School

Department of Chemistry

URI

http://hdl.handle.net/20.500.11937/52637

Collection

Curtin Research Publications

Abstract

Controlling a coil-to-helix transition in peptide-polymer conjugates with soft stimuli requires the careful balancing of stabilizing and destabilizing effects in the peptide segment. The transition between two secondary structures of a bioconjugate is realized using calcium ions to establish a biomimetic control mechanism. Regulation of Ca 2+-ion levels via competitive Ca 2+-ion binders made the process reversible. © 2011 The Royal Society of Chemistry.