Calcium ions as bioinspired triggers to reversibly control the coil-to-helix transition in peptide-polymer conjugates
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Controlling a coil-to-helix transition in peptide-polymer conjugates with soft stimuli requires the careful balancing of stabilizing and destabilizing effects in the peptide segment. The transition between two secondary structures of a bioconjugate is realized using calcium ions to establish a biomimetic control mechanism. Regulation of Ca 2+-ion levels via competitive Ca 2+-ion binders made the process reversible. © 2011 The Royal Society of Chemistry.