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    Anticholinergic burden in older women: not seeing the wood for the trees?

    Access Status
    Fulltext not available
    Authors
    Parkinson, L.
    Magin, P.
    Thomson, A.
    Byles, J.
    Caughey, G.
    Etherton-Beer, C.
    Gnijidic, D.
    Hilmer, S.
    Lo, T.
    McCowan, C.
    Moorin, Rachael
    Pond, D.
    Date
    2015
    Type
    Journal Article
    
    Metadata
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    Citation
    Parkinson, L. and Magin, P. and Thomson, A. and Byles, J. and Caughey, G. and Etherton-Beer, C. and Gnijidic, D. et al. 2015. Anticholinergic burden in older women: not seeing the wood for the trees. Medical Journal of Australia. 202 (2): pp. 91-94.
    Source Title
    Medical Journal of Australia
    DOI
    10.5694/mja14.00336
    ISSN
    0025-729X
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/5333
    Collection
    • Curtin Research Publications
    Abstract

    Objectives: To identify medicines contributing to and describe predictors of anticholinergic burden among community-dwelling older Australian women. Design, setting and participants: Retrospective longitudinal analysis of data from the Australian Longitudinal Study on Women's Health linked to Pharmaceutical Benefits Scheme medicines data from 1 January 2008 to 30 December 2010; for 3694 women born in 1921–1926. Main outcome measures: Anticholinergic burden calculated from Anticholinergic Drug Scale (ADS) scores derived from ADS levels (0 to 3) for all medicines used by each woman, summed over each 6-month period (semester), medicines commonly used by women with high semester ADS scores (defined as 75th percentile of scores). Results: 1126 women (59.9%) used at least one medicine with anticholinergic properties. The median ADS score was 4 or 5 across all semesters. Most anticholinergic medicines used by women who had a high anticholinergic burden (ADS score, = 9) had a low anticholinergic potency (ADS level 1). Increasing age, cardiovascular disease, and number of other medicines used were predictive of a higher anticholinergic burden. Conclusions: A high anticholinergic medicines burden in this group was driven by the use of multiple medicines with lower anticholinergic potency rather than the use of medicines with higher potency. This is a novel and important finding for clinical practice as doctors would readily identify the risk of a high anticholinergic burden for patients using high potency medicines, but may be less likely to identify this risk for users of multiple medicines with low anticholinergic potency.

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