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    Synergistic anticancer effects via co-delivery of TNF-related apoptosis-inducing ligand (TRAIL) and doxorubicin using micellar polymer nanoparticles

    Access Status
    Fulltext not available
    Authors
    Lee, A.
    Dhillon, S.
    Wang, Y.
    Pervaiz, Shazib
    Yang, Y.
    Date
    2012
    Type
    Conference Paper
    
    Metadata
    Show full item record
    Citation
    Lee, A. and Dhillon, S. and Wang, Y. and Pervaiz, S. and Yang, Y. 2012. Synergistic anticancer effects via co-delivery of TNF-related apoptosis-inducing ligand (TRAIL) and doxorubicin using micellar polymer nanoparticles, in 243rd American Chemical Society National Meeting & Exposition, Mar 25-29 2012, Paper 465. San Diego, CA: ACS.
    Source Title
    The American Chemical Society
    Additional URLs
    https://www.acs.org/content/acs/en/meetings/nationalmeetings/programarchive.html
    ISSN
    0065-7727
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/53417
    Collection
    • Curtin Research Publications
    Abstract

    The use of small molecule drugs in cancer chemotherapy has mostly been limited by dose-dependent toxicity and development of drug resistance resulting from repeated administrations. To overcome such problems, efforts have been made to develop drug delivery systems that can bear multiple therapeutic agents in one system. The purpose of this study is to deliver human tumor necrosis factor (TNF) -related apoptosis-inducing ligand (Apo2L/TRAIL) and doxorubicin (Dox, an anti-cancer drug) with micellar nanoparticles self-assembled from a biodegradable cationic copolymer P(MDS-co-CES) to achieve synergistic cytotoxic effects in cancer cells. Effects of nanocomplexes on both wild type and TRAIL-resistant SW480 colorectal carcinoma cells were investigated. Cytotoxicity of the nanocomplexes to non-cancerous cells was significantly lower than cancerous cells. Anti-proliferative effects of nanocomplexes were retained in remaining cancer cells in long-term cultures after treatment with the nanocomplexes. In summary, this Dox and TRAIL co-delivery system can be a promising candidate for cancer treatment.

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    • Synergistic anti-cancer effects via co-delivery of TNF-related apoptosis-inducing ligand (TRAIL/Apo2L) and doxorubicin using micellar nanoparticles
      Lee, A.; Dhillon, S.; Wang, Y.; Pervaiz, Shazib; Fan, W.; Yang, Y. (2011)
      The use of small molecule drugs in cancer chemotherapy has mostly been limited by dose-dependent toxicity and development of drug resistance resulting from repeated administrations. To overcome such problems, efforts have ...
    • Synergistic Anticancer Effects Achieved by Co-Delivery of TRAIL and Paclitaxel Using Cationic Polymeric Micelles
      Lee, A.; Wang, Y.; Pervaiz, Shazib; Fan, W.; Yang, Y. (2011)
      Cationic micellar nanoparticles self-assembled from a biodegradable amphiphilic copolymer have been used to deliver human TRAIL and paclitaxel simultaneously. Polyplexes formed between paclitaxel-loaded nanoparticles and ...
    • Computational modelling of LY303511 and TRAIL-induced apoptosis suggests dynamic regulation of cFLIP
      Shi, Y.; Mellier, G.; Huang, S.; White, J.; Pervaiz, Shazib; Tucker-Kellogg, L. (2013)
      Motivation: TRAIL has been widely studied for the ability to kill cancer cells selectively, but its clinical usefulness has been hindered by the development of resistance. Multiple compounds have been identified that ...
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