Show simple item record

dc.contributor.authorRobman, L.
dc.contributor.authorGuymer, R.
dc.contributor.authorWoods, R.
dc.contributor.authorWard, S.
dc.contributor.authorWolfe, R.
dc.contributor.authorPhung, J.
dc.contributor.authorHodgson, L.
dc.contributor.authorMakeyeva, G.
dc.contributor.authorAung, K.
dc.contributor.authorGilbert, T.
dc.contributor.authorLockery, J.
dc.contributor.authorLe-Pham, Y.
dc.contributor.authorOrchard, S.
dc.contributor.authorStorey, E.
dc.contributor.authorAbhayaratna, W.
dc.contributor.authorReid, D.
dc.contributor.authorErnst, M.
dc.contributor.authorNelson, M.
dc.contributor.authorReid, Christopher
dc.contributor.authorMcNeil, J.
dc.date.accessioned2017-06-23T03:00:16Z
dc.date.available2017-06-23T03:00:16Z
dc.date.created2017-06-19T03:39:37Z
dc.date.issued2017
dc.identifier.citationRobman, L. and Guymer, R. and Woods, R. and Ward, S. and Wolfe, R. and Phung, J. and Hodgson, L. et al. 2017. Age-related macular degeneration in a randomized controlled trial of low-dose aspirin: Rationale and study design of the ASPREE-AMD study. Contemporary Clinical Trials Communications. 6: pp. 105-114.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/53523
dc.identifier.doi10.1016/j.conctc.2017.03.005
dc.description.abstract

Purpose: Although aspirin therapy is used widely in older adults for prevention of cardiovascular disease, its impact on the incidence, progression and severity of age-related macular degeneration (AMD) is uncertain. The effect of low-dose aspirin on the course of AMD will be evaluated in this clinical trial. Design: A sub-study of the ‘ASPirin in Reducing Events in the Elderly’ (ASPREE) trial, ASPREE-AMD is a 5-year follow-up double-blind, placebo-controlled, randomized trial of the effect of 100 mg daily aspirin on the course of AMD in 5000 subjects aged 70 years or older, with normal cognitive function and without cardiovascular disease at baseline. Non-mydriatic fundus photography will be performed at baseline, 3-year and 5-year follow-up to determine AMD status. Primary outcome measures: The incidence and progression of AMD. Exploratory analyses will determine whether aspirin affects the risk of retinal hemorrhage in late AMD, and whether other factors, such as genotype, systemic disease, inflammatory biomarkers, influence the effect of aspirin on AMD. Conclusion: The study findings will be of significant clinical and public interest due to a potential to identify a possible low cost therapy for preventing AMD worldwide and to determine risk/benefit balance of the aspirin usage by the AMD-affected elderly. The ASPREE-AMD study provides a unique opportunity to determine the effect of aspirin on AMD incidence and progression, by adding retinal imaging to an ongoing, large-scale primary prevention randomized clinical trial.

dc.rights.urihttp://creativecommons.org/licenses/by/4.0-nc-nd/
dc.titleAge-related macular degeneration in a randomized controlled trial of low-dose aspirin: Rationale and study design of the ASPREE-AMD study
dc.typeJournal Article
dcterms.source.volume6
dcterms.source.startPage105
dcterms.source.endPage114
dcterms.source.issn2451-8654
dcterms.source.titleContemporary Clinical Trials Communications
curtin.departmentDepartment of Health Policy and Management
curtin.accessStatusOpen access


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

http://creativecommons.org/licenses/by/4.0-nc-nd/
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0-nc-nd/