Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Context-dependent function of ROS in the vascular endothelium: The role of the Notch pathway and shear stress

    Access Status
    Fulltext not available
    Authors
    Vieceli Dalla Sega, F.
    Aquila, G.
    Fortini, F.
    Vaccarezza, Mauro
    Secchiero, P.
    Rizzo, P.
    Campo, G.
    Date
    2017
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Vieceli Dalla Sega, F. and Aquila, G. and Fortini, F. and Vaccarezza, M. and Secchiero, P. and Rizzo, P. and Campo, G. 2017. Context-dependent function of ROS in the vascular endothelium: The role of the Notch pathway and shear stress. BioFactors. 43 (4): pp. 475-485.
    Source Title
    BioFactors (Oxford, England)
    DOI
    10.1002/biof.1359
    ISSN
    0951-6433
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/53525
    Collection
    • Curtin Research Publications
    Abstract

    Reactive oxygen species (ROS) act as signal molecules in several biological processes whereas excessive, unregulated, ROS production contributes to the development of pathological conditions including endothelial dysfunction and atherosclerosis. The maintenance of a healthy endothelium depends on many factors and on their reciprocal interactions; in this framework, the Notch pathway and shear stress (SS) play two lead roles. Recently, evidence of a crosstalk between ROS, Notch, and SS, is emerging. The aim of this review is to describe the way ROS interact with the Notch pathway and SS protecting from-or promoting-the development of endothelial dysfunction.

    Related items

    Showing items related by title, author, creator and subject.

    • Differential, dominant activation and inhibition of notch signalling and APP cleavage by truncations of PSEN1 in human disease deficits
      Newman, M.; Wilson, L.; Verdile, Giuseppe; Lim, A.; Khan, I.; Moussavi Nik, S.; Pursglove, S.; Chapman, G.; Martins, R.; Lardelli, M. (2014)
      PRESENILIN1 (PSEN1) is the major locus for mutations causing familial Alzheimer's disease (FAD) and is also mutated in Pick disease of brain, familial acne inversa and dilated cardiomyopathy. It is a critical facilitator ...
    • Notch Signaling Regulates Immune Responses in Atherosclerosis
      Vieceli Dalla Sega, F.; Fortini, F.; Aquila, G.; Campo, G.; Vaccarezza, Mauro ; Rizzo, P. (2019)
      Atherosclerosis is a chronic autoimmune inflammatory disease that can cause coronary artery disease, stroke, peripheral artery disease, depending on which arteries are affected. At the beginning of atherosclerosis plasma ...
    • Hydrogen-enhanced cracking revealed by in situ micro-cantilever bending test inside environmental scanning electron microscope
      Deng, Y.; Hajilou, T.; Barnoush, Afrooz (2017)
      © 2017 The Author(s) Published by the Royal Society. All rights reserved. To evaluate the hydrogen (H)-induced embrittlement in iron aluminium intermetallics, especially the one with stoichiometric composition of 50 at.% ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.