Context-dependent function of ROS in the vascular endothelium: The role of the Notch pathway and shear stress
Fulltext not available
Vieceli Dalla Sega, F.
MetadataShow full item record
Vieceli Dalla Sega, F. and Aquila, G. and Fortini, F. and Vaccarezza, M. and Secchiero, P. and Rizzo, P. and Campo, G. 2017. Context-dependent function of ROS in the vascular endothelium: The role of the Notch pathway and shear stress. BioFactors. 43 (4): pp. 475-485.
BioFactors (Oxford, England)
School of Biomedical Sciences
Reactive oxygen species (ROS) act as signal molecules in several biological processes whereas excessive, unregulated, ROS production contributes to the development of pathological conditions including endothelial dysfunction and atherosclerosis. The maintenance of a healthy endothelium depends on many factors and on their reciprocal interactions; in this framework, the Notch pathway and shear stress (SS) play two lead roles. Recently, evidence of a crosstalk between ROS, Notch, and SS, is emerging. The aim of this review is to describe the way ROS interact with the Notch pathway and SS protecting from-or promoting-the development of endothelial dysfunction.
Showing items related by title, author, creator and subject.
Differential, dominant activation and inhibition of notch signalling and APP cleavage by truncations of PSEN1 in human disease deficitsNewman, M.; Wilson, L.; Verdile, Giuseppe; Lim, A.; Khan, I.; Moussavi Nik, S.; Pursglove, S.; Chapman, G.; Martins, R.; Lardelli, M. (2014)PRESENILIN1 (PSEN1) is the major locus for mutations causing familial Alzheimer's disease (FAD) and is also mutated in Pick disease of brain, familial acne inversa and dilated cardiomyopathy. It is a critical facilitator ...
Vieceli Dalla Sega, F.; Fortini, F.; Aquila, G.; Campo, G.; Vaccarezza, Mauro ; Rizzo, P. (2019)Atherosclerosis is a chronic autoimmune inflammatory disease that can cause coronary artery disease, stroke, peripheral artery disease, depending on which arteries are affected. At the beginning of atherosclerosis plasma ...
Hydrogen-enhanced cracking revealed by in situ micro-cantilever bending test inside environmental scanning electron microscopeDeng, Y.; Hajilou, T.; Barnoush, Afrooz (2017)© 2017 The Author(s) Published by the Royal Society. All rights reserved. To evaluate the hydrogen (H)-induced embrittlement in iron aluminium intermetallics, especially the one with stoichiometric composition of 50 at.% ...