Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Small surface nanotopography encourages fibroblast and osteoblast cell adhesion

    Access Status
    Fulltext not available
    Authors
    Goreham, R.
    Mierczynska, A.
    Smith, L.
    Sedev, Rossen
    Vasilev, K.
    Date
    2013
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Goreham, R. and Mierczynska, A. and Smith, L. and Sedev, R. and Vasilev, K. 2013. Small surface nanotopography encourages fibroblast and osteoblast cell adhesion. RSC Advances. 3 (26): pp. 10309-10317.
    Source Title
    RSC Advances
    DOI
    10.1039/c3ra23193c
    ISSN
    2046-2069
    School
    Department of Chemical Engineering
    URI
    http://hdl.handle.net/20.500.11937/53569
    Collection
    • Curtin Research Publications
    Abstract

    In this paper, we report the initial response of 3T3 fibroblast and MG63 osteoblast cells to engineered nanotopography gradients of three nanoparticle diameters (16 nm, 38 nm and 68 nm). These nanoengineered surfaces were designed to provide a range of nanoparticle densities and comparable surface area across the gradients of different nanoparticle sizes. Importantly, we provided a uniform surface chemistry in order to be able to examine the effect of pure surface nanotopography. We found that nanotopography features of 16 nm encourage the adhesion of both cell types and that there is a critical nanoparticle density between 50 and 140 particles per µm2 where cells adhered in the greatest numbers. When nanotopography features increased to 38 nm the 3T3 cells adhered and spread well, however, the MG63 cells adhered and spread poorly. Both cell types adhered in lower numbers when the nanotopography feature size increased to 68 nm. This work demonstrates that there is a specific nanotopography scale that encourages cell adhesion and spreading, however, the preferential lateral spacing and height of the nanotopography is different for different cell types.

    Related items

    Showing items related by title, author, creator and subject.

    • Nanoparticles surface treatment on cemented materials for inhibition of bacterial growth
      Noeiaghaei, T.; Dhami, N.; Mukherjee, Abhijit (2017)
      Bacterial growth on cemented materials such as concrete can cause degradation and early ageing. This paper explores the bactericidal characteristics of cementitious materials surface treated with zinc oxide (ZnO) and ...
    • Poly-L-lysine functionalized large pore cubic mesostructured silica nanoparticles as biocompatible carriers for gene delivery
      Hartono, S.; Gu, W.; Kleitz, F.; Liu, Jian; He, L.; Middelberg, A.; Yu, C.; Lu, G.; Qiao, S. (2012)
      Large pore mesoporous silica nanoparticles (LP-MSNs) functionalized with poly-l-lysine (PLL) were designed as a new carrier material for gene delivery applications. The synthesized LP-MSNs are 100-200 nm in diameter and ...
    • Antimicrobial activity of trisodium phosphate and sodium hypochlorite against Salmonella biofilms on abiotic surfaces with and without soiling with chicken juice
      Sarjit, A.; Dykes, Gary (2017)
      Salmonella is a major foodborne pathogen of public health concern and is often associated with contaminated poultry. This pathogen can adhere to surfaces in food processing facilities leading to the formation of biofilms. ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.