Faecal Calprotectin in Treated and Untreated Children With Coeliac Disease and Juvenile Idiopathic Arthritis

Biskou, O.; Gardner-Medwin, J.; Mackinder, M.; Bertz, M.; Clark, C.; Svolos, V.; Russell, R.; Edwards, Christine; McGrogan, P.; Gerasimidis, K.

doi:10.1097/MPG.0000000000001384

Access Status

Fulltext not available

Authors

Biskou, O.

Gardner-Medwin, J.

Mackinder, M.

Bertz, M.

Clark, C.

Svolos, V.

Russell, R.

Edwards, Christine

McGrogan, P.

Gerasimidis, K.

Date

2016

Type

Journal Article

Metadata

Show full item record

Citation

Biskou, O. and Gardner-Medwin, J. and Mackinder, M. and Bertz, M. and Clark, C. and Svolos, V. and Russell, R. et al. 2016. Faecal Calprotectin in Treated and Untreated Children With Coeliac Disease and Juvenile Idiopathic Arthritis. Journal of Pediatric Gastroenterology and Nutrition.

Source Title

Journal of Pediatric Gastroenterology and Nutrition

DOI

10.1097/MPG.0000000000001384

ISSN

0277-2116

Faculty

Faculty of Health Sciences

School

School of Public Health

URI

http://hdl.handle.net/20.500.11937/5409

Collection

Curtin Research Publications

Abstract

© 2016 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology,ABSTRACT: This study aimed to provide evidence on whether children at risk of gastrointestinal inflammation have increased measurements of faecal calprotectin (FC). Faecal calprotectin was measured in 232 children; 55 children (n?=?11 treatment naïve) with juvenile idiopathic arthritis (JIA), 63 with coeliac disease (CD); 17 with new diagnosis before and after treatment on gluten free diet and 114 controls. None of the treatment-naive children with JIA had raised FC. Four JIA patients on treatment had a raised FC but in all cases a repeat test was normal. In newly diagnosed CD patients, the median (IQR) FC was higher 36.4 (26–61) than in controls 25.0 (23–41) mg/kg (p?=?0.045) but this significantly decreased 25 (25–25) mg/kg (p?=?0.012) after six months on gluten free diet. Random measurements of FC are not raised in children with JIA or CD. A significant elevation of FC in these groups is not explained by their diagnosis and therefore needs further investigation.