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dc.contributor.authorAdamska, A.
dc.contributor.authorDomenichini, A.
dc.contributor.authorFalasca, Marco
dc.date.accessioned2017-07-27T05:20:56Z
dc.date.available2017-07-27T05:20:56Z
dc.date.created2017-07-26T11:11:26Z
dc.date.issued2017
dc.identifier.citationAdamska, A. and Domenichini, A. and Falasca, M. 2017. Pancreatic ductal adenocarcinoma: Current and evolving therapies. International Journal of Molecular Science. 18 (7): Article ID 1338.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/54405
dc.identifier.doi10.3390/ijms18071338
dc.description.abstract

Pancreatic ductal adenocarcinoma (PDAC), which constitutes 90% of pancreatic cancers, is the fourth leading cause of cancer-related deaths in the world. Due to the broad heterogeneity of genetic mutations and dense stromal environment, PDAC belongs to one of the most chemoresistant cancers. Most of the available treatments are palliative, with the objective of relieving disease-related symptoms and prolonging survival. Currently, available therapeutic options are surgery, radiation, chemotherapy, immunotherapy, and use of targeted drugs. However, thus far, therapies targeting cancer-associated molecular pathways have not given satisfactory results; this is due in part to the rapid upregulation of compensatory alternative pathways as well as dense desmoplastic reaction. In this review, we summarize currently available therapies and clinical trials, directed towards a plethora of pathways and components dysregulated during PDAC carcinogenesis. Emerging trends towards targeted therapies as the most promising approach will also be discussed.

dc.publisherMDPI AG
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titlePancreatic ductal adenocarcinoma: Current and evolving therapies
dc.typeJournal Article
dcterms.source.volume18
dcterms.source.number7
dcterms.source.issn1661-6596
dcterms.source.titleInternational Journal of Molecular Science
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusOpen access


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