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Susceptibility to non-tuberculous mycobacterial disease is influenced by rs1518111 in IL10

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Open access
Authors
Halstrom, S.
Thomson, R.
Goullee, H.
Baltic, S.
Allcock, R.
Temple, S.
Price, Patricia
Date
2017
Type
Journal Article

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Halstrom, S. and Thomson, R. and Goullee, H. and Baltic, S. and Allcock, R. and Temple, S. and Price, P. 2017. Susceptibility to non-tuberculous mycobacterial disease is influenced by rs1518111 in IL10. Human Immunology. 78 (4): pp. 391-393.
Source Title
Human Immunology
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School of Biomedical Sciences
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Abstract

Although exposure to potentially pathogenic nontuberculous mycobacteria (NTM) via soil and domestic water supplies is common, pulmonary infection and disease are confined to a small proportion of older individuals. Previously, alleles of a polymorphism in IL10 (rs1800896) were associated with NTM disease and we demonstrated elevated production of IL-10 by blood leukocytes from patients with pulmonary NTM. Here seven additional polymorphisms in IL10 were investigated in a larger cohort of Caucasian controls and patients with pulmonary NTM disease. This demonstrated a significant association between pulmonary NTM disease and one polymorphism (rs1518111) in strong linkage disequilibrium with rs1800896.