Oropharyngeal Colostrum Administration in Very Low Birth Weight Infants: A Randomized Controlled Trial
Access Status
Authors
Date
2017Type
Metadata
Show full item recordCitation
Source Title
ISSN
School
Remarks
This is a non-final version of an article published in final form in Zhang, Y. and Ji, F. and Hu, X. and Cao, Y. and Latour, J. 2017. Oropharyngeal Colostrum Administration in Very Low Birth Weight Infants: A Randomized Controlled Trial. Pediatric Critical Care Medicine. 18 (9): pp. 869-875.
Collection
Abstract
Objectives: Studies have confirmed the safety of oropharyngeal administration of colostrum in very low birth weight infants. However, the effect of oropharyngeal administration of colostrum on immune system is inconclusive. This study aims to evaluate the effect of oropharyngeal administration of colostrum on secretory immunoglobulin A and lactoferrin in very low birth weight infants. DESIGN:: Randomized controlled trial. Setting: Forty-bedded neonatal ICU in a university children’s hospital in the People’s Republic of China. Patients: Very low birth weight infants were allocated to the study group (n = 32) and control group (n = 32). Intervention: The intervention was oropharyngeal administration of 0.2 mL of their mother’s colostrum every 4 hours for 7 days. The control group received saline solution. Measurements and Main Results: Secretory immunoglobulin A and lactoferrin in urine and saliva were measured within 24 hours of life (baseline) and at 7 and 21 days. Primary outcomes were changes of secretory immunoglobulin A and lactoferrin in urine and saliva between baseline and at 7 and 21 days. Infant’s clinical data were also collected during hospitalization. Change from baseline in lactoferrin in saliva at 7 days (5.18 ± 7.07 vs –1.74 ± 4.67 µg/mL; p < 0.001) and 21 days (5.31 ± 9.74 vs –1.17 ± 10.38 µg/mL; p = 0.02) shows statistic difference. No differences were found of lactoferrin in urine and also no differences of secretory immunoglobulin A in urine and saliva. There were also no differences between days to full enteral feeding, occurrence rate of clinical sepsis, proven sepsis, and necrotizing enterocolitis. Conclusions: Oropharyngeal administration of colostrum can increases the level of lactoferrin in saliva in very low birth weight infants. No effect could be documented of secretory immunoglobulin A and lactoferrin in urine. Larger trials are needed to better describe the benefit of oropharyngeal administration of colostrum, if any, in very low birth weight infants.
Related items
Showing items related by title, author, creator and subject.
-
Inoue, Madoka (2012)This thesis examines infant feeding practices, including knowledge and attitudes towards breastfeeding, factors that influence the duration of breastfeeding, and breastfeeding outcomes in relation to postpartum women’s ...
-
Cripps, A.; Otczyk, D.; Barker, J.; Lehmann, Deborah; Alpers, Michael Philip (2008)Malnutrition is a significant risk factor for childhood infectious diseases in developing countries, including Papua New Guinea (PNG). Whilst the mechanisms are not fully understood there is little doubt that impairment ...
-
Yu, Chuan (2013)Introduction. The child health is one of the most important indicators of population health and the development of society. The health of children in China has improved in the past decades. The child health care system ...