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dc.contributor.authorQuanjer, P.
dc.contributor.authorHall, Graham
dc.contributor.authorStanojevic, S.
dc.contributor.authorCole, T.
dc.contributor.authorStocks, J.
dc.date.accessioned2017-07-27T05:21:17Z
dc.date.available2017-07-27T05:21:17Z
dc.date.created2017-07-26T11:11:13Z
dc.date.issued2012
dc.identifier.citationQuanjer, P. and Hall, G. and Stanojevic, S. and Cole, T. and Stocks, J. 2012. Age- and height-based prediction bias in spirometry reference equations. European Respiratory Journal. 40 (1): pp. 190-197.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/54492
dc.identifier.doi10.1183/09031936.00161011
dc.description.abstract

Prediction bias in spirometry reference equations can arise from combining equations for different age groups, rounding age or height to integers or using self-reported height. To assess the bias arising from these sources, the fit of 13 prediction equations was tested against the Global Lungs Initiative (GLI) dataset using spirometric data from 55,136 healthy Caucasians (54% female). The effects on predicted values of using whole-year age versus decimal age, and of a 1% bias in height, were quantified. In children, the prediction bias relative to GLI ranged from -22% to +17%. Switching equations at 18 yrs of age led to biases of between -846 (-14%) and +1,309 (+38%) mL. Using age in whole years rather than decimal age introduced biases from -8% to +7%, whereas a 1% overestimation of height introduced bias that ranged from +1% to +40%. Bias was greatest in children and adolescents, and in short elderly subjects. Using a single spirometry equation applicable across all ages and populations reduces prediction bias. Measuring and recording age and height accurately are also essential if bias is to be minimised.

dc.publisherEuropean Respiratory Society
dc.titleAge- and height-based prediction bias in spirometry reference equations
dc.typeJournal Article
dcterms.source.volume40
dcterms.source.number1
dcterms.source.startPage190
dcterms.source.endPage197
dcterms.source.issn0903-1936
dcterms.source.titleEuropean Respiratory Journal
curtin.departmentSchool of Physiotherapy and Exercise Science
curtin.accessStatusOpen access via publisher


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