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dc.contributor.authorManalo, K.
dc.contributor.authorChoong, P.
dc.contributor.authorDass, Crispin
dc.date.accessioned2017-01-30T10:46:21Z
dc.date.available2017-01-30T10:46:21Z
dc.date.created2014-09-02T20:01:14Z
dc.date.issued2011
dc.date.submitted2014-09-03
dc.identifier.citationManalo, K. and Choong, P. and Dass, C. 2011. Pigment Epithelium-Derived Factor as an Impending Therapeutic Agent Against Vascular Epithelial Growth Factor-Driven Tumor-Angiogenesis. Molecular Carcinogenesis. 50 (2): pp. 67-72.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/5453
dc.identifier.doi10.1002/mc.20711
dc.description.abstract

In spite of the recent epidemiological study indicating a positive decrease in cancer trends, cancer remains to be one of the major causes of deaths and there is an anticipated increase in the number of new cancer cases to be recorded in the following years to come. It is important for researchers to improve the current therapeutic agents involved against cancer, particularly targeting to inhibit tumor cell growth, survival, and metastasis. Many researchers investigate the crucial role of a proangiogenic factor, vascular endothelial growth factor (VEGF) in the process of tumor angiogenesis, where the formation of new blood vessels carrying essential nutrients to the tumor cell becomes a critical factor for tumor growth. Since the establishment of VEGF's integral role in mediating tumor angiogenesis and tumor cell survival, current efforts are dedicated to developing therapeutic agents against VEGF and one of the emerging candidate under this category is pigment epithelium-derived factor (PEDF).

dc.publisherJohn Wiley & Sons, Inc.
dc.titlePigment Epithelium-Derived Factor as an Impending Therapeutic Agent Against Vascular Epithelial Growth Factor-Driven Tumor-Angiogenesis
dc.typeJournal Article
dcterms.dateSubmitted2014-09-03
dcterms.source.volume50
dcterms.source.startPage67
dcterms.source.endPage72
dcterms.source.issn0899-1987
dcterms.source.titleMolecular Carcinogenesis
curtin.digitool.pid200264
curtin.pubStatusPublished
curtin.identifier.scriptidPUB-HEA-SPM-AJS-74624
curtin.accessStatusFulltext not available


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