Show simple item record

dc.contributor.authorCoates, A.
dc.contributor.authorWanger, J.
dc.contributor.authorCockcroft, D.
dc.contributor.authorCulver, B.
dc.contributor.authorCarlsen, K.
dc.contributor.authorDiamant, Z.
dc.contributor.authorGauvreau, G.
dc.contributor.authorHall, Graham
dc.contributor.authorHallstrand, T.
dc.contributor.authorHorvath, I.
dc.contributor.authorDe Jongh, F.
dc.contributor.authorJoos, G.
dc.contributor.authorKaminsky, D.
dc.contributor.authorLaube, B.
dc.contributor.authorLeuppi, J.
dc.contributor.authorSterk, P.
dc.identifier.citationCoates, A. and Wanger, J. and Cockcroft, D. and Culver, B. and Carlsen, K. and Diamant, Z. and Gauvreau, G. et al. 2017. ERS technical standard on bronchial challenge testing: General considerations and performance of methacholine challenge tests. European Respiratory Journal. 49 (5): Article ID 1601526.

This international task force report updates general considerations for bronchial challenge testing and the performance of the methacholine challenge test. There are notable changes from prior recommendations in order to accommodate newer delivery devices. Rather than basing the test result upon a methacholine concentration (provocative concentration (PC20) causing a 20% fall in forced expiratory volume in 1 s (FEV1)), the new recommendations base the result upon the delivered dose of methacholine causing a 20% fall in FEV1 (provocative dose (PD20)). This end-point allows comparable results from different devices or protocols, thus any suitable nebuliser or dosimeter may be used, so long as the delivery characteristics are known. Inhalation may be by tidal breathing using a breath-actuated or continuous nebuliser for 1 min (or more), or by a dosimeter with a suitable breath count. Tests requiring maximal inhalations to total lung capacity are not recommended because the bronchoprotective effect of a deep breath reduces the sensitivity of the test.

dc.publisherEuropean Respiratory Society
dc.titleERS technical standard on bronchial challenge testing: General considerations and performance of methacholine challenge tests
dc.typeJournal Article
dcterms.source.titleEuropean Respiratory Journal
curtin.departmentSchool of Physiotherapy and Exercise Science
curtin.accessStatusFulltext not available

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record