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dc.contributor.authorSimpson, S.
dc.contributor.authorStraszek, S.
dc.contributor.authorSly, P.
dc.contributor.authorStick, S.
dc.contributor.authorHall, Graham
dc.date.accessioned2017-07-27T05:21:37Z
dc.date.available2017-07-27T05:21:37Z
dc.date.created2017-07-26T11:11:13Z
dc.date.issued2012
dc.identifier.citationSimpson, S. and Straszek, S. and Sly, P. and Stick, S. and Hall, G. 2012. Clinical investigation of respiratory system admittance in preschool children. Pediatric Pulmonology. 47 (1): pp. 53-58.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/54594
dc.identifier.doi10.1002/ppul.21515
dc.description.abstract

Introduction: The upper airway shunt attenuates measurements of respiratory system impedance (Zrs), with greater impact in young children. Changes in respiratory system admittance, Ars (or Zrs−1), are theoretically independent of the shunt. This study compared the ability of Ars, to standard oscillatory outcomes, to determine respiratory disease and differentiate responses to inhaled bronchial challenges in the clinical setting. Methods: The forced oscillation technique (FOT) was used to establish reference equations for Ars in healthy preschool children, compare the change in Ars to standard oscillatory outcomes during bronchial challenge with inhaled adenosine-5′-monosphate (AMP) and to inhaled bronchodilator in healthy children and those with respiratory disease. Results: Children with respiratory disease had lower baseline Ars than healthy children (P  < 0.05). However, there was no improved ability for Ars to differentiate between bronchodilator responses in healthy and disease populations. In contrast, the response to inhaled AMP occurred at a lower concentration, [25 (3.12–400) mg ml−1; median (10th–90th centile)], as measured by Ars when compared to respiratory system resistance [225 (6.25–400) mg ml−1; P = 0.016]. Conclusion: This study supports the use of Ars during inhaled challenges, but not in response to bronchodilation. Pediatr Pulmonol. Pediatr Pulmonol. 2012; 47:53–58. © 2010 Wiley Periodicals, Inc.

dc.publisherWiley-Liss, Inc
dc.titleClinical investigation of respiratory system admittance in preschool children
dc.typeJournal Article
dcterms.source.volume47
dcterms.source.number1
dcterms.source.startPage53
dcterms.source.endPage58
dcterms.source.issn8755-6863
dcterms.source.titlePediatric Pulmonology
curtin.departmentSchool of Physiotherapy and Exercise Science
curtin.accessStatusFulltext not available


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