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dc.contributor.authorSun, Zhonghua
dc.contributor.authorChaichana, T.
dc.date.accessioned2017-07-27T05:22:17Z
dc.date.available2017-07-27T05:22:17Z
dc.date.created2017-07-26T11:11:19Z
dc.date.issued2016
dc.identifier.citationSun, Z. and Chaichana, T. 2016. Computational fluid dynamic analysis of calcified coronary plaques: Correlation between hemodynamic changes and cardiac image analysis based on left coronary bifurcation angle and lumen assessments. Interventional Cardiology. 8 (6): pp. 713-719.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/54790
dc.identifier.doi10.4172/Interventional-Cardiology.1000543
dc.description.abstract

The purpose of this study was to determine the relationship between left coronary bifurcation angle and significant coronary stenosis with use of coronary CT angiography (CCTA)-generated computational fluid dynamics (CFD) analysis when compared to the CCTA analysis of coronary lumen stenosis with invasive coronary angiography (ICA) as the reference method. Eleven patients with calcified plaques at the left coronary artery tree who underwent CCTA and ICA examinations were included in the study. CFD simulation of left coronary models was performed to analyse hemodynamic changes including wall shear stress, wall pressure and flow velocity. The mean bifurcation angle was measured 83.3 ± 17.1° and 83.3 ± 17.0° on CCTA and ICA, respectively, with no significant difference (p=0.99). Of 15 significant stenosis at left anterior descending (LAD) and left circumflex (LCx) on CCTA, only 3 of them were confirmed to be > 50% stenosis on ICA. Wall shear stress was noted to increase in the LAD and LCx models with significant stenosis and wider angulation (> 80°), but remained no change in most of the other coronary models with no significant stenosis and narrower angulation. Wall pressured was decreased at the significant stenotic lesions, while flow velocity was increased with flow turbulence at the post-stenotic sites. This study further clarifies the direct correlation between left coronary bifurcation angle and significant stenosis, with angulation measurement being more accurate than lumen assessment for diagnosing significant stenosis.

dc.publisherFuture Medicine Ltd
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleComputational fluid dynamic analysis of calcified coronary plaques: Correlation between hemodynamic changes and cardiac image analysis based on left coronary bifurcation angle and lumen assessments
dc.typeJournal Article
dcterms.source.volume8
dcterms.source.number6
dcterms.source.startPage713
dcterms.source.endPage719
dcterms.source.issn1755-5302
dcterms.source.titleInterventional Cardiology
curtin.departmentDepartment of Medical Radiation Sciences
curtin.accessStatusOpen access


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