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dc.contributor.authorMustafa, K.
dc.contributor.authorKeane, Kevin
dc.contributor.authorWalz, N.
dc.contributor.authorMitrovic, K.
dc.contributor.authorHinchliffe, P.
dc.contributor.authorYovich, John
dc.date.accessioned2017-07-27T05:22:21Z
dc.date.available2017-07-27T05:22:21Z
dc.date.created2017-07-26T11:11:26Z
dc.date.issued2017
dc.identifier.citationMustafa, K. and Keane, K. and Walz, N. and Mitrovic, K. and Hinchliffe, P. and Yovich, J. 2017. Live birth rates are satisfactory following multiple IVF treatment cycles in poor prognosis patients. Reproductive Biology. 17 (1): pp. 34-41.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/54820
dc.identifier.doi10.1016/j.repbio.2016.11.004
dc.description.abstract

This seven-year retrospective study analysed the live birth rate (LBR) for women undergoing IVF treatment with various antral follicle counts (AFC). The LBR decreased with lower AFC ratings, and in 290 treatment cycles for women in the poorest AFC category, ≤4 follicles (group E), the LBR was the lowest at 10.7%. The pregnancy loss rate (PLR) significantly increased with poorer AFC categories, from 21.8% in AFC group A (≥20 follicles), to 54.4% in AFC group E (p < 0.0001). This trend was repeated with advancing age, from 21.6% for younger women ( < 35 years), to 32.9, 48.5 and 100% for ages 35–39, 40–44 and ≥45 years, respectively (p < 0.0001). However, LBR within the specific AFC group E cohort was also age-dependent and decreased significantly from 30.0% for <35 years old, to 13.3, 3.9 and 0% for patients aged 35–39, 40–44 and ≥45 years, respectively. Most, importantly, LBR rates within these age groups were not dependent on the number of IVF attempts (1st, 2nd, 3rd or ≥4 cycles), which indicated that cycle number should not be the primary deciding factor for cessation of IVF treatment in responding women <45years old.

dc.titleLive birth rates are satisfactory following multiple IVF treatment cycles in poor prognosis patients
dc.typeJournal Article
dcterms.source.volume17
dcterms.source.number1
dcterms.source.startPage34
dcterms.source.endPage41
dcterms.source.issn1642-431X
dcterms.source.titleReproductive Biology
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusFulltext not available


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