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    Premedication with salbutamol prior to surgery does not decrease the risk of perioperative respiratory adverse events in school-aged children

    Access Status
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    Authors
    Ramgolam, A.
    Hall, Graham
    Sommerfield, D.
    Slevin, L.
    Drake-Brockman, T.
    Zhang, G.
    von Ungern-Sternberg, B.
    Date
    2017
    Type
    Journal Article
    
    Metadata
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    Citation
    Ramgolam, A. and Hall, G. and Sommerfield, D. and Slevin, L. and Drake-Brockman, T. and Zhang, G. and von Ungern-Sternberg, B. 2017. Premedication with salbutamol prior to surgery does not decrease the risk of perioperative respiratory adverse events in school-aged children. British Journal of Anaesthesia. 119 (1): pp. 150-157.
    Source Title
    British Journal of Anaesthesia
    DOI
    10.1093/bja/aex139
    ISSN
    0007-0912
    School
    School of Physiotherapy and Exercise Science
    URI
    http://hdl.handle.net/20.500.11937/55011
    Collection
    • Curtin Research Publications
    Abstract

    Background: Perioperative respiratory adverse events (PRAE) remain the leading cause of morbidity and mortality in the paediatric population. This double-blinded randomized control trial investigated whether inhaled salbutamol premedication decreased the occurrence of PRAE in children identified as being at high risk of PRAE. Methods: Children with at least two parentally reported risk factors for PRAE undergoing elective surgery were eligible for recruitment. They were randomized to receive either salbutamol (200 µg) or placebo prior to their surgery and PRAE (bronchospasm, laryngospasm, airway obstruction, desaturation, coughing and stridor) were recorded. Results: Out of 470 children (6–16 yr, 277 males, 59%) recruited, 462 were available for an intention-to-treat analysis. Thirty-two (14%) and 27 (12%) children from the placebo and salbutamol groups experienced PRAE. This difference was not significant [odds ratio (OR): 0.83, 95% confidence interval (CI): 0.48–1.44, P: 0.51]. Oxygen desaturation [14/232 (6%) vs 14/230 (6%), OR: 1.01, 95% CI: 0.47–2.17, P: 0.98] and severe coughing [12/232 (5%) vs 10/230 (4%), OR: 0.83, 95% CI: 0.35–1.97, P: 0.68] were the most common PRAE, but did not significantly differ between the groups. The occurrence of PRAE was slightly lower in children with respiratory symptoms who received salbutamol compared with placebo [16/134 (12%) vs 21/142 (15%), OR: 0.93, 95% CI: 0.38–2.26, P: 0.87], but was not significantly different. Conclusions: Premedication with salbutamol to children aged between 6 and 16 years and at high risk of PRAE prior to their surgery did not reduce their risk of PRAE. Trial registration number: ACTRN12612000626864 (www.anzctr.org.au).

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