Cognitive deficits in obstructive sleep apnea: Insights from a meta-review and comparison with deficits observed in COPD, insomnia, and sleep deprivation
MetadataShow full item record
© 2017 Elsevier Ltd. Obstructive sleep apnea (OSA) is a nocturnal breathing disorder that is associated with cognitive impairment. The primary determinants of cognitive deficits in OSA are thought to be sleep disruption and blood gas abnormalities. Cognitive impairment is also seen in other disorders that are characterised primarily by sleep disturbance (e.g., sleep restriction/deprivation, insomnia) or hypoxia/hypercarbia (e.g., chronic obstructive pulmonary disease (COPD)). Assessment of the cognitive deficits observed in these other disorders could help better define the mechanisms underlying cognitive deficits in OSA. This study utilised meta-review methodology to examine the findings from systematic reviews and meta-analyses of the effects of untreated OSA, COPD, insomnia, and sleep deprivation on cognitive function in adults, compared with norms or controls. Eighteen papers met inclusion criteria: seven in OSA, two in insomnia, five in COPD, and four in sleep deprivation. OSA and COPD were both accompanied by deficits in attention, memory, executive function, psychomotor function, and language abilities, suggesting that hypoxia/hypercarbia may be an important determinant of deficits in these domains in OSA. Both OSA and sleep deprivation studies were accompanied by deficits in attention and memory, suggesting that short-term sleep disturbance in OSA may contribute to deficits in these domains. Visuospatial deficits were unique to OSA, suggesting the contribution of a mechanism other than sleep disturbance and hypoxia/hypercarbia to this problem. Our findings suggest that the cognitive deficits associated with untreated OSA are multidimensional, with different physiological disturbances responsible for differing cognitive problems.
Showing items related by title, author, creator and subject.
Individuals with clinically significant insomnia symptoms are characterised by a negative sleep-related expectancy bias: Results from a cognitive-experimental assessmentCourtauld, H.; Notebaert, L.; Milkins, B.; Kyle, S.; Clarke, Patrick (2017)© 2017 Elsevier LtdCognitive models of insomnia consistently suggest that negative expectations regarding the consequences of poor sleep contribute to the maintenance of insomnia. To date, however, no research has sought ...
The potential benefits of targeted attentional bias modification on cognitive arousal and sleep quality in worry-related sleep disturbanceMilkins, B.; Notebaert, L.; MacLeod, C.; Clarke, Patrick (2016)Attentional bias for sleep-related negative information is believed to contribute to symptoms of insomnia by elevating arousal during the presleep period. In the present study, we examined whether the delivery of an ...
Analysis of nocturnal actigraphic sleep measures in patients with COPD and their association with daytime physical activitySpina, G.; Spruit, M.; Alison, J.; Benzo, R.; Calverley, P.; Clarenbach, C.; Costello, R.; Donaire-Gonzalez, D.; Dürr, S.; Garcia-Aymerich, J.; van Gestel, A.; Gramm, M.; Hernandes, N.; Hill, Kylie; Hopkinson, N.; Jarreta, D.; Kohler, M.; Kirsten, A.; Leuppi, J.; Magnussen, H.; Maltais, F.; Man, W.; McKeough, Z.; Mesquita, R.; Miedinger, D.; Pitta, F.; Singh, S.; Smeenk, F.; Tal-Singer, R.; Vagaggini, B.; Waschki, B.; Watz, H.; Wouters, E.; Zogg, S.; den Brinker, A. (2017)Background: Sleep disturbances are common in patients with chronic obstructive pulmonary disease (COPD) with a considerable negative impact on their quality of life. However, factors associated with measures of sleep in ...