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    Solubility of Bicalutamide, Megestrol Acetate, Prednisolone, Beclomethasone Dipropionate, and Clarithromycin in Subcritical Water at Different Temperatures from 383.15 to 443.15 K

    Access Status
    Fulltext not available
    Authors
    Pu, Y.
    Cai, F.
    Wang, D.
    Li, Y.
    Chen, X.
    Maimouna, A.
    Wu, Z.
    Wen, X.
    Chen, J.
    Foster, Neil
    Date
    2017
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Pu, Y. and Cai, F. and Wang, D. and Li, Y. and Chen, X. and Maimouna, A. and Wu, Z. et al. 2017. Solubility of Bicalutamide, Megestrol Acetate, Prednisolone, Beclomethasone Dipropionate, and Clarithromycin in Subcritical Water at Different Temperatures from 383.15 to 443.15 K. Journal of Chemical & Engineering Data. 62 (3): pp. 1139-1145.
    Source Title
    Journal of Chemical & Engineering Data
    DOI
    10.1021/acs.jced.6b00997
    ISSN
    0021-9568
    School
    Department of Chemical Engineering
    URI
    http://hdl.handle.net/20.500.11937/55256
    Collection
    • Curtin Research Publications
    Abstract

    © 2017 American Chemical Society. The solubility of bicalutamide, megestrol acetate, prednisolone, beclomethasone dipropionate, and clarithromycin in subcritical water (SBCW) at the temperature range from 383.15 to 443.15 K and constant pressure of 5.5 MPa were measured using a modified solvent-antisolvent method combined with SBCW technology. The chemical structures of these five kinds of solutes were stable after processed in SBCW at up to 443.15 K, which was demonstrated by Fourier transformed infrared analysis. The solubility of selected solutes increased exponentially as the temperature of the SBCW increased from 383.15 to 443.15 K. The obtained solubility data were correlated using a modified Apelblat model and the results of the predicted solubility show good agreement with the experimental value. (Graph Presented).

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