Solubility of Bicalutamide, Megestrol Acetate, Prednisolone, Beclomethasone Dipropionate, and Clarithromycin in Subcritical Water at Different Temperatures from 383.15 to 443.15 K

Pu, Y.; Cai, F.; Wang, D.; Li, Y.; Chen, X.; Maimouna, A.; Wu, Z.; Wen, X.; Chen, J.; Foster, Neil

doi:10.1021/acs.jced.6b00997

Access Status

Fulltext not available

Authors

Pu, Y.

Cai, F.

Wang, D.

Li, Y.

Chen, X.

Maimouna, A.

Wu, Z.

Wen, X.

Chen, J.

Foster, Neil

Date

2017

Type

Journal Article

Metadata

Show full item record

Citation

Pu, Y. and Cai, F. and Wang, D. and Li, Y. and Chen, X. and Maimouna, A. and Wu, Z. et al. 2017. Solubility of Bicalutamide, Megestrol Acetate, Prednisolone, Beclomethasone Dipropionate, and Clarithromycin in Subcritical Water at Different Temperatures from 383.15 to 443.15 K. Journal of Chemical & Engineering Data. 62 (3): pp. 1139-1145.

Source Title

Journal of Chemical & Engineering Data

DOI

10.1021/acs.jced.6b00997

ISSN

0021-9568

School

Department of Chemical Engineering

URI

http://hdl.handle.net/20.500.11937/55256

Collection

Curtin Research Publications

Abstract

© 2017 American Chemical Society. The solubility of bicalutamide, megestrol acetate, prednisolone, beclomethasone dipropionate, and clarithromycin in subcritical water (SBCW) at the temperature range from 383.15 to 443.15 K and constant pressure of 5.5 MPa were measured using a modified solvent-antisolvent method combined with SBCW technology. The chemical structures of these five kinds of solutes were stable after processed in SBCW at up to 443.15 K, which was demonstrated by Fourier transformed infrared analysis. The solubility of selected solutes increased exponentially as the temperature of the SBCW increased from 383.15 to 443.15 K. The obtained solubility data were correlated using a modified Apelblat model and the results of the predicted solubility show good agreement with the experimental value. (Graph Presented).