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    Particle formation of budesonide from alcohol-modified subcritical water solutions

    Access Status
    Fulltext not available
    Authors
    Carr, A.
    Mammucari, R.
    Foster, Neil
    Date
    2011
    Type
    Journal Article
    
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    Citation
    Carr, A. and Mammucari, R. and Foster, N. 2011. Particle formation of budesonide from alcohol-modified subcritical water solutions. International Journal of Pharmaceutics. 405 (1-2): pp. 169-180.
    Source Title
    International Journal of Pharmaceutics
    DOI
    10.1016/j.ijpharm.2010.11.042
    ISSN
    0378-5173
    School
    Department of Chemical Engineering
    URI
    http://hdl.handle.net/20.500.11937/55293
    Collection
    • Curtin Research Publications
    Abstract

    Recently, subcritical water (SBCW: water that has been heated to a temperature between 100 °C and 200 °C at pressures of up to 70 bar) has been used to dissolve several hydrophobic pharmaceutical compounds (Carr et al., 2010a). Furthermore, a number of active pharmaceutical ingredients (APIs) have been rapidly precipitated from SBCW solutions (Carr et al., 2010b,c). It is possible to alter the precipitate morphology by altering the processing variables; including the SBCW-API solution injection temperature and adding impurities (such as pharmaceutical excipients, e.g. lactose) to the precipitation chamber. The work presented in this article demonstrates that the morphology of pharmaceutical particles can be tuned by adding organic solvents (ethanol and methanol) to the SBCW-API solutions. Particle morphology has also been tuned by adding different pharmaceutical excipients (polyethylene glycol 400 and lactose) to the precipitation chamber. Different morphologies of pharmaceutical particles were produced, ranging from nanospheres of 60 nm diameter to 5 µm plate particles. Budesonide was used as the model API in this study. Two experimental products were spray dried to form dry powder products. The aerodynamic particle size of the powder was established by running the powder through an Andersen Cascade Impactor. It has been shown that the drug particles produced from the SBCW micronization process, when coupled with a spray drying process, are suitable for delivery to the lungs.© 2010 Elsevier B.V. All rights reserved.

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