Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4<sup>+</sup> T Cell Differentiation via PI3K p110d-Akt-Mediated Signals
MetadataShow full item record
© 2017 The Author(s) Low-grade systemic inflammation associated to obesity leads to cardiovascular complications, caused partly by infiltration of adipose and vascular tissue by effector T cells. The signals leading to T cell differentiation and tissue infiltration during obesity are poorly understood. We tested whether saturated fatty acid-induced metabolic stress affects differentiation and trafficking patterns of CD4 + T cells. Memory CD4 + T cells primed in high-fat diet-fed donors preferentially migrated to non-lymphoid, inflammatory sites, independent of the metabolic status of the hosts. This was due to biased CD4 + T cell differentiation into CD44 hi -CCR7 lo -CD62L lo -CXCR3 + -LFA1 + effector memory-like T cells upon priming in high-fat diet-fed animals. Similar phenotype was observed in obese subjects in a cohort of free-living people. This developmental bias was independent of any crosstalk between CD4 + T cells and dendritic cells and was mediated via direct exposure of CD4 + T cells to palmitate, leading to increased activation of a PI3K p110d-Akt-dependent pathway upon priming.
Showing items related by title, author, creator and subject.
Toll-like receptor (TLR) expression on CD4+ and CD8+ T-cells in patients chronically infected with hepatitis C virusHammond, T.; Lee, S.; Watson, M.; Flexman, J.; Cheng, W.; Fernandez, S.; Price, Patricia (2010)Toll-like receptor (TLR) expression on T-cells and the signalling pathways that lead to the production of cytokines may limit antigen-specific T-cell responses. Here, expression of TLR and retinoic acid inducible gene I ...
Cytomegalovirus infection alters phenotypes of different ?d T-cell subsets in renal transplant recipients with long-term stable graft functionLee, S.; Affandi, Jacquita; Irish, A.; Price, P. (2017)© 2017 Wiley Periodicals, Inc. Cytomegalovirus (CMV) infection alters the phenotypic profiles of T-cells and NK cells in healthy and immunocompromised individuals. Here, we examined the effects of CMV infection on the ...
Impaired function of regulatory T-cells in patients with chronic obstructive pulmonary disease (COPD)Tan, D.; Fernandez, S.; Price, Patricia; French, M.; Thompson, P.; Moodley, Y. (2014)Anti-inflammatory pathways affecting chronic obstructive pulmonary disease (COPD) are poorly understood. Regulatory T-cells (Tregs) are important negative regulators of T-cell activity and hence were investigated in COPD ...