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    High density lipoproteins and atherosclerosis: Emerging aspects

    Access Status
    Fulltext not available
    Authors
    Sala, F.
    Catapano, A.
    Norata, Giuseppe
    Date
    2012
    Type
    Journal Article
    
    Metadata
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    Citation
    Sala, F. and Catapano, A. and Norata, G. 2012. High density lipoproteins and atherosclerosis: Emerging aspects. Journal of Geriatric Cardiology. 9 (4): pp. 401-407.
    Source Title
    Journal of Geriatric Cardiology
    DOI
    10.3724/SP.J.1263.2011.12282
    ISSN
    1671-5411
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/55372
    Collection
    • Curtin Research Publications
    Abstract

    High density lipoproteins (HDL) promote the efflux of excess cholesterol from peripheral tissues to the liver for excretion. This ability is responsible for the most relevant antiatherogenic effect of HDL. The ability of HDL to promote cholesterol efflux results also in the modulation of a series of responses in the immune cells involved in atherosclerosis, including monocyte-macrophages, B and T lymphocytes. Furthermore, during inflammation, the composition of this class of lipoproteins varies to a large extent, thus promoting the formation of dysfunctional HDL. The aim of this review is to discuss the emerging role of HDL in modulating the activity of immune cells and immune-inflammatory mediators during atherogenesis. © 2012 JGC All rights reserved.

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