The Cellular and Molecular Basis of Translational Immunometabolism
MetadataShow full item record
© 2015 Elsevier Inc. The immune response requires major changes to metabolic processes, and indeed, energy metabolism and functional activation are fully integrated in immune cells to determine their ability to divide, differentiate, and carry out effector functions. Immune cell metabolism has therefore become an attractive target area for therapeutic purposes. A neglected aspect in the translation of immunometabolism is the critical connection between systemic and cellular metabolism. Here, we discuss the importance of understanding and manipulating the integration of systemic and immune cell metabolism through in-depth analysis of immune cell phenotype and function in human metabolic diseases and, in parallel, of the effects of conventional metabolic drugs on immune cell differentiation and function. We examine how the recent identification of selective metabolic programs operating in distinct immune cell subsets and functions has the potential to deliver tools for cell- and function-specific immunometabolic targeting.
Showing items related by title, author, creator and subject.
Keane, Kevin; Calton, E.; Carlessi, Rodrigo; Hart, P.; Newsholme, Philip (2017)Diabetes mellitus is one of the most common chronic metabolic disorders worldwide, and its incidence in Asian countries is alarmingly high. Type 2 diabetes (T2DM) is closely associated with obesity, and the staggering ...
Cruzat, Vinicius; Rogero, M.; Keane, Kevin; Curi, R.; Newsholme, Philip (2018)© 2018 by the authors. Licensee MDPI, Basel, Switzerland. Glutamine is the most abundant and versatile amino acid in the body. In health and disease, the rate of glutamine consumption by immune cells is similar or greater ...
Newsholme, Philip; Cruzat, Vinicius; Keane, Kevin; Carlessi, Rodrigo; de Bittencourt, P. (2016)Oxidative stress and chronic inflammation are known to be associated with the development of metabolic diseases, including diabetes. Oxidative stress, an imbalance between oxidative and antioxidative systems of cells and ...