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    Role of epigenetic modulation in cancer stem cell fate

    Access Status
    Fulltext not available
    Authors
    Deshmukh, A.
    Binju, M.
    Arfuso, Frank
    Newsholme, Philip
    Dharmarajan, Arunasalam
    Date
    2017
    Type
    Journal Article
    
    Metadata
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    Citation
    Deshmukh, A. and Binju, M. and Arfuso, F. and Newsholme, P. and Dharmarajan, A. 2017. Role of epigenetic modulation in cancer stem cell fate. International Journal of Biochemistry and Cell Biology. 90: pp. 9-16.
    Source Title
    International Journal of Biochemistry and Cell Biology
    DOI
    10.1016/j.biocel.2017.07.003
    ISSN
    1357-2725
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/55734
    Collection
    • Curtin Research Publications
    Abstract

    © 2017 Elsevier Ltd A sub-population of the tumor micro-environment consists of cancer stem cells (CSCs), which are responsible for the initiation and recurrence of cancer. Recently, epigenetic processes such as DNA methylation, histone modification, and chromatin remodeling have been found to be involved in inducing epigenetic factors in CSCs. Most of these processes, such as DNA methylation, generally occur in the genome that is rich in Cytosine-Guanine repeat sequences, also known as CpG islands, which are distributed throughout the human genome. The Polycomb gene (PcG) complex is a chromatin modifier facilitating the maintenance of embryonic and adult stem cells. Recent evidence suggests that the PcG is also involved in maintaining CSC stemness. We have presented various aspects and examples of how epigenetic modulation may drive or promote tumorigenesis and metastasis by alteration of key transcriptomic programs and signaling pathways in CSCs.

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