Waning vaccine immunity in teenagers primed with whole cell and acellular pertussis vaccine: Recent epidemiology
|dc.identifier.citation||Sheridan, S. and Frith, K. and Snelling, T. and Grimwood, K. and McIntyre, P. and Lambert, S. 2014. Waning vaccine immunity in teenagers primed with whole cell and acellular pertussis vaccine: Recent epidemiology. Expert Review of Vaccines. 13 (9): pp. 1081-1106.|
The recent epidemics of pertussis (whooping cough) in parts of the USA and Australia have led to the largest numbers of annual cases reported in over half a century. These epidemics demonstrated a new pattern, with particularly high rates of disease among pre-adolescents and early adolescents. These high rates of pertussis coincided with the first cohorts vaccinated with purely acellular pertussis vaccine, which replaced whole-cell pertussis (wP) vaccine in the later 1990s in the USA and Australia. Studies undertaken during these epidemics provide new evidence of more rapid waning of acellular pertussis-containing vaccines and longer-term protection from effective wP-containing vaccines. There is evidence that receiving wP as at least the first dose of pertussis-containing vaccine provides greater and more long-lived protection, irrespective of the nature of subsequent doses. This evidence will be reviewed together with the immunobiology associated with both vaccines, and the implications for pertussis control discussed. © 2014 Informa UK, Ltd.
|dc.title||Waning vaccine immunity in teenagers primed with whole cell and acellular pertussis vaccine: Recent epidemiology|
|dcterms.source.title||Expert Review of Vaccines|
|curtin.department||School of Public Health|
|curtin.accessStatus||Fulltext not available|
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