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dc.contributor.authorAmmirati, E.
dc.contributor.authorCianflone, D.
dc.contributor.authorVecchio, V.
dc.contributor.authorBanfi, M.
dc.contributor.authorVermi, A.
dc.contributor.authorDe Metrio, M.
dc.contributor.authorGrigore, L.
dc.contributor.authorPellegatta, F.
dc.contributor.authorPirillo, A.
dc.contributor.authorGarlaschelli, K.
dc.contributor.authorManfredi, A.
dc.contributor.authorCatapano, A.
dc.contributor.authorMaseri, A.
dc.contributor.authorPalini, A.
dc.contributor.authorNorata, Giuseppe
dc.identifier.citationAmmirati, E. and Cianflone, D. and Vecchio, V. and Banfi, M. and Vermi, A. and De Metrio, M. and Grigore, L. et al. 2012. Effector memory T cells are associated with atherosclerosis in humans and animal models. Journal of the American Heart Association. 1 (1): pp. 27-41.

Background- Adaptive T-cell response is promoted during atherogenesis and results in the differentiation of näive CD4 + T cells to effector and/or memory cells of specialized T-cell subsets. Aim of this work was to investigate the relationship between circulating CD4 + T-cell subsets and atherosclerosis. Methods and Results- We analyzed 57 subsets of circulating CD4+T cells by 10-parameter/8-color polychromatic flow cytometry (markers: CD3/CD4/CD45RO/CD45RA/CCR7/CCR5/CXCR3/HLA-DR) in peripheral blood from 313 subjects derived from 2 independent cohorts. In the first cohort of subjects from a free-living population (n=183), effector memory T cells (T EM : CD3 + CD4 + CD45RA - CD45RO + CCR7- cells) were strongly related with intima-media thickness of the common carotid artery, even after adjustment for age (r=0.27; P < 0.001). Of note, a significant correlation between T EM and low-density lipoproteins was observed. In the second cohort (n=130), T EM levels were significantly increased in patients with chronic stable angina or acute myocardial infarction compared with controls. HLA-DR+T EM were the T EM subpopulation with the strongest association with the atherosclerotic process (r=0.37; P < 0.01). Finally, in animal models of atherosclerosis, T EM (identified as CD4 + CD44 + CD62L - ) were significantly increased in low-density lipoprotein receptor and apolipoprotein E deficient mice compared with controls and were correlated with the extent of atherosclerotic lesions in the aortic root (r=0.56; P < 0.01). Conclusions- Circulating T EM cells are associated with increased atherosclerosis and coronary artery disease in humans and in animal models and could represent a key CD4 + T-cell subset related to the atherosclerotic process. © 2012. The Authors.

dc.titleEffector memory T cells are associated with atherosclerosis in humans and animal models
dc.typeJournal Article
dcterms.source.titleJournal of the American Heart Association
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusOpen access via publisher

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