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    Novel concepts in HDL pharmacology

    Access Status
    Open access via publisher
    Authors
    Remaley, A.
    Norata, Giuseppe
    Catapano, A.
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Remaley, A. and Norata, G. and Catapano, A. 2014. Novel concepts in HDL pharmacology. Cardiovascular Research. 103 (3): pp. 423-428.
    Source Title
    Cardiovascular Research
    DOI
    10.1093/cvr/cvu141
    ISSN
    0008-6363
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/55846
    Collection
    • Curtin Research Publications
    Abstract

    High-density lipoproteins (HDL) are a target for drug development because of their proposed anti-atherogenic properties. In this review, we will briefly discuss the currently established drugs for increasing HDL-C, namely niacin and fibrates, and some of their limitations. Next, we will focus on novel alternative therapies that are currently being developed for raising HDL-C, such as CETP inhibitors. Finally, we will conclude with a review of novel drugs that are being developed for modulating the function of HDL based on HDL mimetics. Gaps in our knowledge and the challenges that will have to be overcome for these new HDL based therapies will also be discussed. © Published by Oxford University Press on behalf of the European Society of Cardiology 2014.

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