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dc.contributor.authorKurniawansyah, F.
dc.contributor.authorMammucari, R.
dc.contributor.authorTandya, A.
dc.contributor.authorFoster, Neil
dc.identifier.citationKurniawansyah, F. and Mammucari, R. and Tandya, A. and Foster, N. 2017. Scale - Up and economic evaluation of the atomized rapid injection solvent extraction process. Journal of Supercritical Fluids. 127: pp. 208-216.

© 2017 Elsevier B.V. The Atomized Rapid Injection Solvent Extraction (ARISE) process is a new technique for the production of micron-size particles using a supercritical antisolvent. Scale-up of the process can be achieved simply by maintaining the antisolvent/solvent ratios and pressure differentials while increasing batch volumes. In this work, two model compounds, para-coumaric acid (PCA) and hydroxypropyl-ß-cyclodextrin (HPßCD), were processed using ARISE at different operating scales. The batch size for PCA varied between 0.2 g/batch and 1.6 g/batch, while the batch size of HPßCD varied from 0.8 g/batch to 13.9 g/batch. The economic evaluation of the process was based on production rates between 2 and 10 t/a, which are typical for high-specialty grade chemicals. Capital investment and production costs were estimated using the scaling–exponential method. Investment costs were estimated between 190 and 950 US$/kg of product while production costs were calculated between 52 and 255 US$/kg of product (year 2015). The figures indicate that ARISE can be economically viable for the manufacturing of specialty chemicals as pharmaceuticals.

dc.publisherElsevier BV
dc.titleScale - Up and economic evaluation of the atomized rapid injection solvent extraction process
dc.typeJournal Article
dcterms.source.titleJournal of Supercritical Fluids
curtin.departmentDepartment of Chemical Engineering
curtin.accessStatusFulltext not available

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