Scale - Up and economic evaluation of the atomized rapid injection solvent extraction process
dc.contributor.author | Kurniawansyah, F. | |
dc.contributor.author | Mammucari, R. | |
dc.contributor.author | Tandya, A. | |
dc.contributor.author | Foster, Neil | |
dc.date.accessioned | 2017-08-24T02:21:39Z | |
dc.date.available | 2017-08-24T02:21:39Z | |
dc.date.created | 2017-08-23T07:21:43Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Kurniawansyah, F. and Mammucari, R. and Tandya, A. and Foster, N. 2017. Scale - Up and economic evaluation of the atomized rapid injection solvent extraction process. Journal of Supercritical Fluids. 127: pp. 208-216. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/55964 | |
dc.identifier.doi | 10.1016/j.supflu.2017.03.006 | |
dc.description.abstract |
© 2017 Elsevier B.V. The Atomized Rapid Injection Solvent Extraction (ARISE) process is a new technique for the production of micron-size particles using a supercritical antisolvent. Scale-up of the process can be achieved simply by maintaining the antisolvent/solvent ratios and pressure differentials while increasing batch volumes. In this work, two model compounds, para-coumaric acid (PCA) and hydroxypropyl-ß-cyclodextrin (HPßCD), were processed using ARISE at different operating scales. The batch size for PCA varied between 0.2 g/batch and 1.6 g/batch, while the batch size of HPßCD varied from 0.8 g/batch to 13.9 g/batch. The economic evaluation of the process was based on production rates between 2 and 10 t/a, which are typical for high-specialty grade chemicals. Capital investment and production costs were estimated using the scaling–exponential method. Investment costs were estimated between 190 and 950 US$/kg of product while production costs were calculated between 52 and 255 US$/kg of product (year 2015). The figures indicate that ARISE can be economically viable for the manufacturing of specialty chemicals as pharmaceuticals. | |
dc.publisher | Elsevier BV | |
dc.title | Scale - Up and economic evaluation of the atomized rapid injection solvent extraction process | |
dc.type | Journal Article | |
dcterms.source.volume | 127 | |
dcterms.source.startPage | 208 | |
dcterms.source.endPage | 216 | |
dcterms.source.issn | 0896-8446 | |
dcterms.source.title | Journal of Supercritical Fluids | |
curtin.department | Department of Chemical Engineering | |
curtin.accessStatus | Fulltext not available |
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