Novel biotinylated bile acid amphiphiles: Micellar aggregates formation and interaction with hepatocytes

Rizzi, L.; Braschi, M.; Colombo, M.; Vaiana, N.; Tibolla, G.; Norata, Giuseppe; Catapano, A.; Romeo, S.; Prosperi, D.

doi:10.1039/c0ob00878h

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Authors

Rizzi, L.

Braschi, M.

Colombo, M.

Vaiana, N.

Tibolla, G.

Norata, Giuseppe

Catapano, A.

Romeo, S.

Prosperi, D.

Date

2011

Type

Journal Article

Metadata

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Citation

Rizzi, L. and Braschi, M. and Colombo, M. and Vaiana, N. and Tibolla, G. and Norata, G. and Catapano, A. et al. 2011. Novel biotinylated bile acid amphiphiles: Micellar aggregates formation and interaction with hepatocytes. Organic and Biomolecular Chemistry. 9 (8): pp. 2899-2905.

Source Title

Organic and Biomolecular Chemistry

DOI

10.1039/c0ob00878h

ISSN

1477-0520

School

School of Biomedical Sciences

URI

http://hdl.handle.net/20.500.11937/56167

Collection

Curtin Research Publications

Abstract

Amphiphilic bile acids linked through an oligoethylene glycol to a biotin moiety were synthesized and shown to create micellar structures in aqueous environment, interact with avidin and be efficiently incorporated into hepatocyte cells, suggesting their potential as a drug delivery system against liver diseases. © 2011 The Royal Society of Chemistry.