Novel biotinylated bile acid amphiphiles: Micellar aggregates formation and interaction with hepatocytes
Fulltext not available
MetadataShow full item record
Rizzi, L. and Braschi, M. and Colombo, M. and Vaiana, N. and Tibolla, G. and Norata, G. and Catapano, A. et al. 2011. Novel biotinylated bile acid amphiphiles: Micellar aggregates formation and interaction with hepatocytes. Organic and Biomolecular Chemistry. 9 (8): pp. 2899-2905.
Organic and Biomolecular Chemistry
School of Biomedical Sciences
Amphiphilic bile acids linked through an oligoethylene glycol to a biotin moiety were synthesized and shown to create micellar structures in aqueous environment, interact with avidin and be efficiently incorporated into hepatocyte cells, suggesting their potential as a drug delivery system against liver diseases. © 2011 The Royal Society of Chemistry.