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    Encapsulation of superparamagnetic iron oxide nanoparticles by the supercritical antisolvent process

    Access Status
    Fulltext not available
    Authors
    Lam, U.
    Yoganathan, R.
    Carr, A.
    Mammucari, R.
    Foster, Neil
    Date
    2012
    Type
    Journal Article
    
    Metadata
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    Citation
    Lam, U. and Yoganathan, R. and Carr, A. and Mammucari, R. and Foster, N. 2012. Encapsulation of superparamagnetic iron oxide nanoparticles by the supercritical antisolvent process. Australian Journal of Chemistry. 65 (1): pp. 40-44.
    Source Title
    Australian Journal of Chemistry
    DOI
    10.1071/CH11360
    ISSN
    0004-9425
    School
    Department of Chemical Engineering
    URI
    http://hdl.handle.net/20.500.11937/56205
    Collection
    • Curtin Research Publications
    Abstract

    The aim of the experiments in this research was to produce a coated superparamagnetic iron oxide nanoparticle (SPION) product that may be used as a contrasting agent for MRI. There are several methods that can be employed to coat SPIONs. However, many of the current methods employ toxic organic solvents which can be difficult to remove from the product solution. The encapsulation and characterization of SPIONs in Eudragit was done using a supercritical antisolvent system (SAS) with ethanol as the solvent and supercritical carbon dioxide (SC-CO 2 ) as the antisolvent. Particles of diameters less than 200nm were produced which had preserved superparamagnetic properties. An encapsulation efficiency of 70% was achieved. This compilation © CSIRO 2011.

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