Gene silencing approaches for the management of dyslipidaemia
MetadataShow full item record
The key role of dyslipidaemias in determining cardiovascular risk has been well established, and statins often provide effective therapeutic management. However, many patients do not achieve recommended lipid levels despite maximal therapy, and some cannot tolerate high-dose statin therapy. Recently, genetic insights into mechanisms underlying regulation of lipoprotein metabolism have expanded the potential targets of drug therapy and led to the development of novel agents, including development of gene silencing approaches. These therapeutic options include the modulation of synthesis in the liver, maturation in the circulation, and catabolism of lipoproteins. In this review, we discuss the pharmacological consequences of silencing apolipoprotein B, apolipoprotein (a), microRNA 33, proprotein convertase subtilisin/kexin type 9, and apolipoprotein C-III. New potential targets such as other microRNAs, diacylglycerol acyl transferase-1, and angiopoietin-like protein 3 are also presented. The pharmacological consequences of gene silencing and the advancement of these therapeutic approaches in clinical development will be examined. © 2013 Elsevier Ltd.
Showing items related by title, author, creator and subject.
To all the bodies I have loved before : the marginalisation of non-homosexual male-male corporeal pleasures in the discourse of gay liberationDurber, Dean A. (2004)In the post-gay liberation era, the body desirous of same-sex sex is presented with the possibility of existing without punishment. Indeed, gay liberation has demanded freedom for this body, insisting that the journey ...
Perceptions of Jordanian children with cancer regarding concealing the true nature of their diagnosis: An interpretive phenomenological analysis studyAl Omar, O.; Wynaden, Dianne (2013)An interpretative phenomenological analysis approach was used to explore and document the experiences of children diagnosed with cancer regarding the true nature of their diagnosis in the first three months after diagnosis. ...
Epigenetic regulation of the secreted frizzled-related protein family in human glioblastoma multiformeSchiefer, L.; Visweswaran, Malini; Perumal, Vanathi; Arfuso, Frank; Groth, David; Newsholme, Philip; Warrier, Sudha; Dharmarajan, Arunasalam (2014)Glioblastoma multiforme (GBM) are intracranial tumors of the central nervous system and the most lethal among solid tumors. Current therapy is palliative and is limited to surgical resection followed by radiation therapy ...