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    Management of invasive group A streptococcal infections

    Access Status
    Fulltext not available
    Authors
    Waddington, C.
    Snelling, Thomas
    Carapetis, J.
    Date
    2014
    Type
    Journal Article
    
    Metadata
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    Citation
    Waddington, C. and Snelling, T. and Carapetis, J. 2014. Management of invasive group A streptococcal infections. Journal of Infection. 69 (S1): pp. S63-S69.
    Source Title
    Journal of Infection
    DOI
    10.1016/j.jinf.2014.08.005
    ISSN
    0163-4453
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/56279
    Collection
    • Curtin Research Publications
    Abstract

    © 2014. Invasive group A streptococcal (GAS) disease in children includes deep soft tissue infection, bacteraemia, bacteraemic pneumonia, meningitis and osteomyelitis. The expression of toxins and super antigens by GAS can complicate infection by triggering an overwhelming systemic inflammatory response, referred to as streptococcal toxic shock syndrome (STSS). The onset and progression of GAS disease can be rapid, and the associated mortality high. Prompt antibiotics therapy and early surgical debridement of infected tissue are essential. Adjunctive therapy with intravenous immunoglobulin and hyperbaric therapy may improve outcomes in severe disease. Nosocomial outbreaks and secondary cases in close personal contacts are not uncommon; infection control measures and consideration of prophylactic antibiotics to those at high risk are important aspects of disease control. To reduce a substantial part of the global burden of GAS disease, an affordable GAS vaccine with efficacy against a broad number of strains is needed.

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