Management of invasive group A streptococcal infections
MetadataShow full item record
© 2014. Invasive group A streptococcal (GAS) disease in children includes deep soft tissue infection, bacteraemia, bacteraemic pneumonia, meningitis and osteomyelitis. The expression of toxins and super antigens by GAS can complicate infection by triggering an overwhelming systemic inflammatory response, referred to as streptococcal toxic shock syndrome (STSS). The onset and progression of GAS disease can be rapid, and the associated mortality high. Prompt antibiotics therapy and early surgical debridement of infected tissue are essential. Adjunctive therapy with intravenous immunoglobulin and hyperbaric therapy may improve outcomes in severe disease. Nosocomial outbreaks and secondary cases in close personal contacts are not uncommon; infection control measures and consideration of prophylactic antibiotics to those at high risk are important aspects of disease control. To reduce a substantial part of the global burden of GAS disease, an affordable GAS vaccine with efficacy against a broad number of strains is needed.
Showing items related by title, author, creator and subject.
TNF block haplotypes reveal diverse pathways between TNF and disease: Implications for understanding neuropathy in HIV patientsChew, C.; Valente, F.; Wallace, H.; Tan, J.; Temple, S.; Price, Patricia (2012)The region spanning the tumor necrosis factor (TNF) cluster in the human major histocompatibility complex (MHC) has been implicated in susceptibility to numerous immunopathological and inflammatory diseases. However, ...
Incidence, risk factors, and outcomes of Panton-Valentine leukocidin-positive methicillin-susceptible staphylococcus aureus infections in Auckland, New ZealandMuttaiyah, S.; Coombs, Geoffrey; Pandey, S.; Reed, P.; Ritchie, S.; Lennon, D.; Roberts, S. (2010)Panton-Valentine leukocidin (PVL) has been linked to invasive community-acquired methicillin-resistant Staphylococcus aureus infections. However, the association between disease and PVL-positive methicillin- susceptible ...
Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990–2013: quantifying the epidemiological transitionMiller, Ted (2015)Summary Background The Global Burden of Disease Study 2013 (GBD 2013) aims to bring together all available epidemiological data using a coherent measurement framework, standardised estimation methods, and transparent ...