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    Apolipoprotein C-III: From Pathophysiology to Pharmacology

    Access Status
    Fulltext not available
    Authors
    Norata, Giuseppe
    Tsimikas, S.
    Pirillo, A.
    Catapano, A.
    Date
    2015
    Type
    Journal Article
    
    Metadata
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    Citation
    Norata, G. and Tsimikas, S. and Pirillo, A. and Catapano, A. 2015. Apolipoprotein C-III: From Pathophysiology to Pharmacology. Trends in Pharmacological Sciences. 36 (10): pp. 675-687.
    Source Title
    Trends in Pharmacological Sciences
    DOI
    10.1016/j.tips.2015.07.001
    ISSN
    0165-6147
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/56381
    Collection
    • Curtin Research Publications
    Abstract

    © 2015 Elsevier Ltd. All rights reserved. Apolipoprotein C-III (apoC-III) has a critical role in the metabolism of triglyceride (TG)-rich lipoproteins (TRLs). Animal models lacking the APOC3 gene exhibit reduced plasma TG levels, whereas the overexpression of APOC3 leads to increased TG levels. In humans, loss-of-function mutations in APOC3 are associated with reduced plasma TG levels and reduced risk for ischemic vascular disease and coronary heart disease. Several hypolipidemic agents have been shown to reduce apoC-III, including fibrates and statins, and antisense technology aimed at inhibiting APOC3 mRNA to decrease the production of apoC-III is currently in Phase III of clinical development. Here, we review the pathophysiological role of apoC-III in TG metabolism and the evidence supporting this apolipoprotein as an emerging target for hypertriglyceridemia (HTG) and associated cardiovascular disorders.

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