T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP
dc.contributor.author | Perruzza, L. | |
dc.contributor.author | Gargari, G. | |
dc.contributor.author | Proietti, M. | |
dc.contributor.author | Fosso, B. | |
dc.contributor.author | D'Erchia, A. | |
dc.contributor.author | Faliti, C. | |
dc.contributor.author | Rezzonico-Jost, T. | |
dc.contributor.author | Scribano, D. | |
dc.contributor.author | Mauri, L. | |
dc.contributor.author | Colombo, D. | |
dc.contributor.author | Pellegrini, G. | |
dc.contributor.author | Moregola, A. | |
dc.contributor.author | Mooser, C. | |
dc.contributor.author | Pesole, G. | |
dc.contributor.author | Nicoletti, M. | |
dc.contributor.author | Norata, Giuseppe | |
dc.contributor.author | Geuking, M. | |
dc.contributor.author | McCoy, K. | |
dc.contributor.author | Guglielmetti, S. | |
dc.contributor.author | Grassi, F. | |
dc.date.accessioned | 2017-08-24T02:23:43Z | |
dc.date.available | 2017-08-24T02:23:43Z | |
dc.date.created | 2017-08-23T07:21:47Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Perruzza, L. and Gargari, G. and Proietti, M. and Fosso, B. and D'Erchia, A. and Faliti, C. and Rezzonico-Jost, T. et al. 2017. T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP. Cell Reports. 18 (11): pp. 2566-2575. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/56397 | |
dc.identifier.doi | 10.1016/j.celrep.2017.02.061 | |
dc.description.abstract |
© 2017 The Authors The ATP-gated ionotropic P2X7 receptor regulates T follicular helper (Tfh) cell abundance in the Peyer's patches (PPs) of the small intestine; deletion of P2rx7, encoding for P2X7, in Tfh cells results in enhanced IgA secretion and binding to commensal bacteria. Here, we show that Tfh cell activity is important for generating a diverse bacterial community in the gut and that sensing of microbiota-derived extracellular ATP via P2X7 promotes the generation of a proficient gut ecosystem for metabolic homeostasis. The results of this study indicate that Tfh cells play a role in host-microbiota mutualism beyond protecting the intestinal mucosa by induction of affinity-matured IgA and suggest that extracellular ATP constitutes an inter-kingdom signaling molecule important for selecting a beneficial microbial community for the host via P2X7-mediated regulation of B cell help. | |
dc.title | T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP | |
dc.type | Journal Article | |
dcterms.source.volume | 18 | |
dcterms.source.number | 11 | |
dcterms.source.startPage | 2566 | |
dcterms.source.endPage | 2575 | |
dcterms.source.issn | 2211-1247 | |
dcterms.source.title | Cell Reports | |
curtin.department | School of Biomedical Sciences | |
curtin.accessStatus | Open access via publisher |
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