Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Risk of persistent or recurrent cervical neoplasia in patients with 'pure' adenocarcinoma-in-situ (AIS) or mixed AIS and high-grade cervical squamous neoplasia (cervical intra-epithelial neoplasia grades 2 and 3 (CIN 2/3)): A population-based study

    255581.pdf (504.0Kb)
    Access Status
    Open access
    Authors
    Codde, E.
    Munro, A.
    Stewart, C.
    Spilsbury, Katrina
    Bowen, S.
    Codde, J.
    Steel, N.
    Leung, Y.
    Tan, J.
    Salfinger, S.
    Mohan, G.
    Cohen, P.
    Date
    2017
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Codde, E. and Munro, A. and Stewart, C. and Spilsbury, K. and Bowen, S. and Codde, J. and Steel, N. et al. 2017. Risk of persistent or recurrent cervical neoplasia in patients with 'pure' adenocarcinoma-in-situ (AIS) or mixed AIS and high-grade cervical squamous neoplasia (cervical intra-epithelial neoplasia grades 2 and 3 (CIN 2/3)): A population-based study. BJOG: An International Journal of Obstetrics and Gynaecology. 125 (1): pp. 74–79.
    Source Title
    BJOG: An International Journal of Obstetrics and Gynaecology
    DOI
    10.1111/1471-0528.14808
    ISSN
    1470-0328
    School
    Centre for Population Health Research
    Remarks

    This is the peer reviewed version of the following article: Codde, E. and Munro, A. and Stewart, C. and Spilsbury, K. and Bowen, S. and Codde, J. and Steel, N. et al. 2017. Risk of persistent or recurrent cervical neoplasia in patients with 'pure' adenocarcinoma-in-situ (AIS) or mixed AIS and high-grade cervical squamous neoplasia (cervical intra-epithelial neoplasia grades 2 and 3 (CIN 2/3)): A population-based study. BJOG: An International Journal of Obstetrics and Gynaecology. 125 (1): pp. 74–79, which has been published in final form at 10.1111/1471-0528.14808. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving at http://olabout.wiley.com/WileyCDA/Section/id-828039.html

    URI
    http://hdl.handle.net/20.500.11937/56636
    Collection
    • Curtin Research Publications
    Abstract

    Objective: To compare outcomes of patients with pure adenocarcinoma-in-situ (AIS) and mixed AIS/CIN 2/3 lesions including the incidence of AIS persistence, recurrence and progression to adenocarcinoma. Design: Retrospective cohort study. Setting: Statewide population in Western Australia. Population: Women diagnosed with AIS between 2001 and 2012. Methods: We conducted a retrospective, population-based cohort study. Main outcome measures: De-identified linked data were utilised to ascertain the association between patient age at excisional treatment, margin status, lesion type, lesion size, and risk of persistent AIS (defined as the presence of AIS < 12 months from treatment), recurrent AIS (=12 months post-treatment), and adenocarcinoma. Results: 636 patients were eligible for analysis. The mean age was 32.3 years and median follow-up interval was 2.5 years. Within the study cohort, 266 patients (41.8%) had pure AIS and 370 (58.2%) had mixed AIS/CIN 2/3. Overall, 47 patients (7.4%) had AIS persistence/recurrence and 12 (1.9%) had adenocarcinoma. Factors associated with persistence/recurrence were pure AIS (hazard ratio (HR) 2.3; 95%CI 1.28-3.94; P = 0.005), age > 30 years (HR 2.1; 95%CI 1.16-3.81; P = 0.015), positive endocervical margins (HR 5.8; 95%CI 3.05-10.92; P = < 0.001) and AIS lesions > 8 mm (HR 2.5; 95%CI 1.00-6.20; P = 0.049). A histologically positive AIS ectocervical margin was not associated with persistence/recurrence. Conclusion: In this study, pure AIS was associated with greater risk of persistence/recurrence than was mixed AIS/CIN 2/3. AIS lesions > 8 mm and positive endocervical margins were significant predictors for persistent or recurrent disease. Tweetable Abstract: Pure cervical adenocarcinoma-in-situ (AIS) may have greater risk of recurrence than AIS co-existing with CIN 2/3.

    Related items

    Showing items related by title, author, creator and subject.

    • Risk of persistent and recurrent cervical neoplasia following incidentally detected adenocarcinoma-in-situ.
      Munro, A.; Codde, J.; Spilsbury, Katrina; Steel, N.; Stewart, C.; Salfinger, S.; Tan, J.; Mohan, G.; Leung, Y.; Semmens, James; O'Leary, Peter; Williams, Vincent; Cohen, P. (2017)
      BACKGROUND: Adenocarcinoma-in-situ (AIS) of the uterine cervix is a precursor to cervical adenocarcinoma and may co-exist with both adenocarcinoma and high-grade squamous dysplasia (cervical intraepithelial neoplasia (CIN) ...
    • Comparison of cold knife cone biopsy and loop electrosurgical excision procedure in the management of cervical adenocarcinoma in situ: What is the gold standard?
      Munro, A.; Leung, Y.; Spilsbury, Katrina; Stewart, C.; Semmens, James; Codde, Jim; Williams, Vincent; O'Leary, Peter; Steel, N.; Cohen, P.; Cohen, P. (2015)
      Objective: To compare the outcomes of patients with cervical adenocarcinoma in situ (ACIS) treated with cold knife cone (CKC) biopsy or loop electrosurgical excision procedure (LEEP) for the treatment of cervical ...
    • Risk of persistent or recurrent neoplasia in conservatively treated women with cervical adenocarcinoma in situ with negative histological margins
      Munro, A.; Codde, J.; Spilsbury, Katrina; Stewart, C.; Steel, N.; Leung, Y.; Tan, J.; Salfinger, S.; Mohan, G.; Semmens, James; Cohen, P. (2017)
      INTRODUCTION: Conservative treatments including cold knife cone biopsy (CKC) or loop electrosurgical excision procedure (LEEP) are fertility-preserving alternatives to hysterectomy. The risks of persistent cervical neoplasia ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.