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    A pilot randomised controlled trial of modafinil during acute methamphetamine withdrawal: Feasibility, tolerability and clinical outcomes

    Access Status
    Open access via publisher
    Authors
    Lee, N.
    Pennay, A.
    Hester, R.
    McKetin, Rebecca
    Nielsen, S.
    Ferris, J.
    Date
    2013
    Type
    Journal Article
    
    Metadata
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    Citation
    Lee, N. and Pennay, A. and Hester, R. and McKetin, R. and Nielsen, S. and Ferris, J. 2013. A pilot randomised controlled trial of modafinil during acute methamphetamine withdrawal: Feasibility, tolerability and clinical outcomes. Drug and Alcohol Review. 32 (1).
    Source Title
    Drug and Alcohol Review
    DOI
    10.1111/j.1465-3362.2012.00473.x
    ISSN
    0959-5236
    School
    National Drug Research Institute (NDRI)
    URI
    http://hdl.handle.net/20.500.11937/56651
    Collection
    • Curtin Research Publications
    Abstract

    Introduction and Aims: There are no medications approved for the treatment of methamphetamine withdrawal. Wake-promoting agent modafinil has recently been proposed as a viable option. This paper reports on the results of a pilot study that tested the feasibility of modafinil in an inpatient withdrawal setting during acute methamphetamine withdrawal. Design and Methods: In a double-blind, randomised, placebo-controlled study, 19 methamphetamine dependent participants received modafinil (n=9) or placebo (n=10) daily for 7days (200mg for the first 5days and 100mg on days 6 and 7). Primary outcomes were retention in treatment and severity of withdrawal symptoms. Second ary outcomes were methamphetamine craving, sleep and physiological outcomes. Results: There were no significant differences between groups on retention in treatment, withdrawal severity, craving, sleep or physiological outcomes. There were no adverse events or side-effects reported. Conclusions: Modafinil was found to be tolerable and well accepted by methamphetamine users and feasible for short-term inpatient withdrawal, but the sample was too small to detect treatment effects. Larger trials are needed to establish efficacy.

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