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dc.contributor.authorYudi, M.
dc.contributor.authorHamilton, G.
dc.contributor.authorFarouque, O.
dc.contributor.authorAndrianopoulos, N.
dc.contributor.authorDuffy, S.
dc.contributor.authorLefkovits, J.
dc.contributor.authorBrennan, A.
dc.contributor.authorFernando, D.
dc.contributor.authorHiew, C.
dc.contributor.authorFreeman, M.
dc.contributor.authorReid, Christopher
dc.contributor.authorDakis, R.
dc.contributor.authorAjani, A.
dc.contributor.authorClark, D.
dc.identifier.citationYudi, M. and Hamilton, G. and Farouque, O. and Andrianopoulos, N. and Duffy, S. and Lefkovits, J. and Brennan, A. et al. 2017. Trends and Impact of Door-to-Balloon Time on Clinical Outcomes in Patients Aged <75, 75 to 84, and ≥8585 Years With ST-Elevation Myocardial Infarction. American Journal of Cardiology.

Guidelines strongly recommend patients with ST-elevation myocardial infarction (STEMI) receive timely mechanical reperfusion, defined as door-to-balloon time (DTBT) =90 minutes. The impact of timely reperfusion on clinical outcomes in patients aged 75-84 and =85 years is uncertain. We analysed 2,972 consecutive STEMI patients who underwent primary percutaneous coronary intervention from the Melbourne Interventional Group Registry (2005-2014). Patients aged < 75 years were included in the younger group, those aged 75-84 years were in the elderly group and those =85 years were in the very elderly group. The primary endpoints were 12-month mortality and major adverse cardiovascular events (MACE). 2,307 (77.6%) patients were < 75 years (mean age 59 ± 9 years), 495 (16.7%) were 75-84 years and 170 (5.7%) were =85 years. There has been a significant decrease in DTBT over 10 years in younger and elderly patients (p-for-trend < 0.01 and 0.03) with a trend in the very elderly (p-for-trend 0.08). Compared to younger and elderly patients, the very elderly had higher 12-month mortality (3.6% vs 10.7% vs. 29.4%; p = 0.001) and MACE (10.8% vs 20.6% vs 33.5%; p = 0.001). DTBT =90 minutes was associated with improved outcomes on univariate analysis but was not an independent predictor of improved 12-month mortality (OR 0.84, 95% CI 0.54-1.31) or MACE (OR 0.89, 95% CI 0.67-1.16). In conclusion, over a 10-year period, there was an improvement in DTBT in patients aged < 75 years and 75-84 years however DTBT =90 minutes was not an independent predictor of 12-month outcomes. Thus assessing whether patients aged =85 years are suitable for invasive management does not necessarily translate to worse clinical outcomes.

dc.publisherExcerpta Medica, Inc
dc.titleTrends and Impact of Door-to-Balloon Time on Clinical Outcomes in Patients Aged <75, 75 to 84, and ≥8585 Years With ST-Elevation Myocardial Infarction
dc.typeJournal Article
dcterms.source.titleAmerican Journal of Cardiology
curtin.departmentDepartment of Health Policy and Management
curtin.accessStatusFulltext not available

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