Increased Carbohydrate Intake is Associated with Poorer Performance in Verbal Memory and Attention in an APOE Genotype-Dependent Manner
MetadataShow full item record
Evidence suggests that a diet low in carbohydrates can impact on cognitive performance among those with Alzheimer's disease (AD). However, there is a lack of data assessing this relationship among cognitively normal (CN) older adults at increased future risk of developing AD due to carriage of the apolipoprotein E (APOE) ?4 allele. We assessed the cross-sectional association between carbohydrate intake, cognitive performance, and cerebral amyloid-ß (Aß) load in CN older adults, genotyped for APOE ?4 allele carrier status. Greater carbohydrate intake was associated with poorer performance in verbal memory in APOE ?4 allele non-carriers, and poorer performance in attention in APOE ?4 allele carriers. There were no associations between carbohydrate intake and cerebral Aß load. These results provide support to the idea that decreasing carbohydrate intake may offer neurocognitive benefits, with specific cognitive domains affected in an APOE genotype-dependent manner. These findings warrant further investigation utilizing a longitudinal study design.
Showing items related by title, author, creator and subject.
Lack of reliable evidence for a distinctive ε4-related cognitive phenotype that is independent from clinical diagnostic status: findings from the Australian Imaging, Biomarkers and Lifestyle StudyFoster, Jonathan; Albrecht, Matthew; Savage, Greg; Lautenschlager, Nicola T.; Ellis, Kathryn A.; Maruff, Paul; Szoeke, Cassandra; Taddei, Kevin; Martins, Ralph; Masters, Colin L.; Ames, David (2013)Individuals who carry the apolipoprotein E ε4 polymorphism have an increased risk of late-onset Alzheimer’s disease. However, because possession of the ε4 allele confers an increased risk for the diagnosis of dementia, ...
Nyaradi, A.; Foster, J.; Hickling, S.; Li, Jianghong; Ambrosini, G.; Jacques, A.; Oddy, W. (2014)Background: The aim of the study was to investigate prospective associations between dietary patterns and cognitive performance during adolescence .Methods: Participants were sourced from the Western Australian Pregnancy ...
A Polygenic Risk Score Derived From Episodic Memory Weighted Genetic Variants Is Associated With Cognitive Decline in Preclinical Alzheimer's DiseasePorter, T.; Burnham, S.; Savage, G.; Lim, Y.; Maruff, P.; Milicic, L.; Peretti, M.; Ames, D.; Masters, C.; Martins, R.; Rainey-Smith, S.; Rowe, C.; Salvado, O.; Taddei, K.; Groth, David; Verdile, Giuseppe; Villemagne, V.; Laws, Simon (2018)Studies of Alzheimer's disease risk-weighted polygenic risk scores (PRSs) for cognitive performance have reported inconsistent associations. This inconsistency is particularly evident when PRSs are assessed independent ...