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    A potential role for N-acetylcysteine in the management of methamphetamine dependence

    Access Status
    Fulltext not available
    Authors
    McKetin, Rebecca
    Dean, O.
    Baker, A.
    Carter, G.
    Turner, A.
    Kelly, P.
    Berk, M.
    Date
    2017
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    McKetin, R. and Dean, O. and Baker, A. and Carter, G. and Turner, A. and Kelly, P. and Berk, M. 2017. A potential role for N-acetylcysteine in the management of methamphetamine dependence. Drug and Alcohol Review. 36 (2): pp. 153-159.
    Source Title
    Drug and Alcohol Review
    DOI
    10.1111/dar.12414
    ISSN
    0959-5236
    School
    National Drug Research Institute (NDRI)
    URI
    http://hdl.handle.net/20.500.11937/56773
    Collection
    • Curtin Research Publications
    Abstract

    Methamphetamine dependence is a growing problem in Australia and globally. Currently, there are no approved pharmacotherapy options for the management of methamphetamine dependence. N-acetylcysteine is one potential pharmacotherapy option. It has received growing attention as a therapy for managing addictions because of its capacity to restore homeostasis to brain glutamate systems disrupted in addiction and thereby reduce craving and the risk of relapse. N-acetylcysteine also has antioxidant properties that protect against methamphetamine-induced toxicity and it may therefore assist in the management of the neuropsychiatric and neurocognitive effects of methamphetamine. This commentary overviews the actions of N-acetylcysteine and evidence for its efficacy in treating addiction with a particular focus on its potential utility for methamphetamine dependence. We conclude that the preliminary evidence indicates a need for full-scale trials to definitively establish whether N-acetylcysteine has a therapeutic benefit and the nature of this benefit, for managing methamphetamine dependence. [McKetin R, Dean O, Baker A. L, Carter G, Turner A, Kelly P. J, Berk M. A potential role for N-acetylcysteine in the management of methamphetamine dependence.

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