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    Human Papillomavirus Associated Cancers of the Head and Neck: An Australian Perspective

    Access Status
    Fulltext not available
    Authors
    Aldalwg, M.
    Brestovac, Brian
    Date
    2017
    Type
    Journal Article
    
    Metadata
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    Citation
    Aldalwg, M. and Brestovac, B. 2017. Human Papillomavirus Associated Cancers of the Head and Neck: An Australian Perspective. Head and Neck Pathology. 11 (3): pp. 377-384.
    Source Title
    Head and Neck Pathology
    DOI
    10.1007/s12105-017-0780-7
    ISSN
    1936-055X
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/56804
    Collection
    • Curtin Research Publications
    Abstract

    © 2017, Springer Science+Business Media New York. Human papillomavirus (HPV) associated head and neck squamous cell carcinomas (HNSCCs), have become a serious global health problem. Despite decreases in HPV-negative HNSCCs, the prevalence of HPV-positive HNSCCs has significantly increased. HPV-positive cancers are associated with superior survival outcomes when compared to HPV-negative cancers, which appears likely to be associated with differences in the molecular pathogenesis of the two diseases. While therapies are still problematic, the current HPV vaccine programs hold a promise for the primary prevention of HPV-related HNSCCs and since Australia was the first to introduce a nationwide HPV vaccine program, it is in a unique position to observe the effects of the vaccine on HNSCCs. This review discusses the epidemiological trends associated with HPV in HNSCC, with reference to the differences between HPV-positive and HPV-negative HNSCCs and the prevention potential of HPV vaccines.

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