The Implications of DNA Methylation on Food Allergy
MetadataShow full item record
Food allergy is a major clinical and public health concern worldwide. The risk factors are well defined, however, the mechanisms by which they affect immune development remain largely unknown, and unfortunately the effective treatment or prevention of food allergy is still being researched. Recent studies show that the genes that are critical for the development of food allergy are regulated through DNA methylation. Environmental factors can affect host DNA methylation status and subsequently predispose people to food allergy. DNA methylation is therefore an important mediator of gene-environment interactions in food allergy and key to understanding the mechanisms underlying the allergic development. Indeed, the modification and identification of the methylation levels of specific genetic loci have gained increasing attention for therapeutic and diagnostic application in combating food allergy. In this review, we summarize and discuss the recent developments of DNA methylation in food allergy, including the pathogenesis, therapy, and diagnosis. This review will also summarize and discuss the environmental factors that affect DNA methylation levels in food allergy.
Showing items related by title, author, creator and subject.
Jones, A.; Palmer, D.; Zhang, Guicheng; Prescott, S. (2012)OBJECTIVE: There has been growing interest in vitamin D insufficiency as a predisposing factor for allergy development based on immunoregulatory properties and epidemiological studies. The aim of this study was to investigate ...
Infant feeding and allergy prevention: A review of current knowledge and recommendations. A EuroPrevall state of the art paperGrimshaw, K.; Allen, K.; Edwards, Christine; Beyer, K.; Boulay, A.; Van Der Aa, L.; Sprikkelman, A.; Belohlavkova, S.; Clausen, M.; Dubakiene, R.; Duggan, E.; Reche, M.; Marino, L.; Nørhede, P.; Ogorodova, L.; Schoemaker, A.; Stanczyk-Przyluska, A.; Szepfalusi, Z.; Vassilopoulou, E.; Veehof, S.; Vlieg-Boerstra, B.; Wjst, M.; Dubois, A. (2009)The relationship between infant feeding patterns and the later development of food allergies has been the focus of much debate and research over the last decade. National recommendations have been made by many countries ...
Khoo, S.; Mäkelä, M.; Chandler, D.; Schultz, E.; Jamieson, S.; Goldblatt, J.; Haahtela, T.; LeSouëf, P.; Zhang, Guicheng (2016)Background: Finnish and Russian Karelian children have a highly contrasting occurrence of asthma and allergy. In these two environments, we studied associations between total serum immunoglobulin E (IgE) with methylation ...