Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Impact of early conversion from cyclosporin to everolimus on left ventricular mass index: A randomized controlled trial

    Access Status
    Fulltext not available
    Authors
    Krishnan, A.
    Teixeira-Pinto, A.
    Chan, D.
    Chakera, Aron
    Dogra, G.
    Boudville, N.
    Irish, A.
    Morgan, K.
    Phillips, J.
    Wong, G.
    Lim, W.
    Date
    2017
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Krishnan, A. and Teixeira-Pinto, A. and Chan, D. and Chakera, A. and Dogra, G. and Boudville, N. and Irish, A. et al. 2017. Impact of early conversion from cyclosporin to everolimus on left ventricular mass index: A randomized controlled trial. Clinical Transplantation. 31 (10): pp. e13043.
    Source Title
    Clinical Transplantation
    DOI
    10.1111/ctr.13043
    ISSN
    0902-0063
    School
    Curtin Medical School
    URI
    http://hdl.handle.net/20.500.11937/56971
    Collection
    • Curtin Research Publications
    Abstract

    This is an 18-month prospective, randomized controlled trial (RCT) designed to compare the effect of early conversion from cyclosporin to everolimus/mycophenolic acid (E-MPA) between 3 and 4 months post-transplant to cyclosporin/mycophenolic acid (CsA-MPA) on left ventricular mass index (LVMI) at 3 and 18 months post-transplant (primary outcome). Secondary outcomes included estimated glomerular filtration rate (eGFR), viral infection, and adverse events. Twenty-four patients were randomized in a 1:1 ratio to E-MPA or CsA-MPA groups. There were no significant differences in mean (SD) LVMI at 3 (51.6±18.5 vs 53.7±15.7 g/m 2.7 ) and 18 months (52.7±16.3 vs 51.7±16.8 g/m 2.7 ) between CsA-MPA and E-MPA groups. The incidence of viral infections was reduced in E-MPA compared to CsA-MPA treatment groups (8% vs 50%, P=.02), but the incidences of acute rejection, adverse events, and drug discontinuation were similar between groups. There was an overall increase in eGFR with time (0.04 log- mL/min/1.73 m 2 per 6 months, P=.012) but no significant difference between the two groups across time (0.11 log- mL/min/1.73 m 2 , P=.311). Immunosuppressive regimen comprising early conversion from cyclosporine to everolimus was not associated with a regression of LVMI, but a lower risk of viral infections was observed.

    Related items

    Showing items related by title, author, creator and subject.

    • Breastfeeding and health outcomes in infants who receive continuing care from hospitals or community health centres in Chengdu Sichuan Province, People’s Republic of China
      Yu, Chuan (2013)
      Introduction. The child health is one of the most important indicators of population health and the development of society. The health of children in China has improved in the past decades. The child health care system ...
    • The role of functional, radiological and self-reported measures in predicting clinical outcome in spondylotic cervical radiculopathy
      Agarwal, Shabnam (2011)
      BackgroundCervical radiculopathy (CR) results in significant disability and pain and is commonly treated conservatively with satisfactory clinical outcomes. However, a considerable number of patients require surgery to ...
    • Valence state of titanium in the Wark-Lovering rim of a Leoville CAI as a record of progressive oxidation in the early Solar Nebula
      Dyl, Kathryn; Simon, J.; Young, E. (2011)
      Simon et al. (2005) reported low Ti3+/Ti4+ values in Ti-rich pyroxenes in the Wark-Lovering rim (WL) of a Leoville CAI (144A) as compared to the interior of the inclusion. These electron microprobe analyses were interpreted ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.