The Molecular Pathogenesis of Osteosarcoma: A Review
MetadataShow full item record
Osteosarcoma is the most common primary malignancy of bone. It arises in bone during periods of rapid growth and primarily affects adolescents and young adults. The 5-year survival rate for osteosarcoma is 60-70, with no significant improvements in prognosis since the advent of multiagent chemotherapy. Diagnosis, staging, and surgical management of osteosarcoma remain focused on our anatomical understanding of the disease. As our knowledge of the molecular pathogenesis of osteosarcoma expands, potential therapeutic targets are being identified. A comprehensive understanding of these mechanisms is essential if we are to improve the prognosis of patients with osteosarcoma through tumour-targeted therapies. This paper will outline the pathogenic mechanisms of osteosarcoma oncogenesis and progression and will discuss some of the more frontline translational studies performed to date in search of novel, safer, and more targeted drugs for disease management.
Showing items related by title, author, creator and subject.
Systemically administered PEDF against primary and secondary tumours in a clinically relevant osteosarcoma modelBroadhead, M.; Dass, Crispin; Choong, P. (2011)Background: Pigment epithelium-derived factor (PEDF) is an endogenous glycoprotein with a potential role as a therapeutic for osteosarcoma. Animal studies have demonstrated the biological effects of PEDF on osteosarcoma; ...
Ouyang, Z.; Li, H.; Zhai, Z.; Xu, J.; Dass, Crispin; Qin, A.; Dai, K. (2018)© 2018 Bentham Science Publishers. Background: Osteosarcoma is considered the most frequent primary bone malignancy. Lung metastasis is the leading cause of death and the most consistent factor for predicting negative ...
Efficacy of Continuously Administered PEDF-Derived Synthetic Peptides against Osteosarcoma Growth and MetastasisBroadhead, M.; Choong, P.; Dass, Crispin (2012)The potent antiangiogenic pigment epithelium-derived factor (PEDF) has shown promise against osteosarcoma, a tumour that originates in the bone and metastasises to the lungs. Neurotrophic, antiangiogenic, antiproliferative, ...