The role of vitamin D status in the bioenergetics of inflammation
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This thesis investigates the role of vitamin D metabolites 1,25-dihydroxyvitamin D and 25-hydroxyvitamin D in human bioenergetics and inflammation. The evidence presented comes from a narrative review, two systematic reviews, two cross-sectional studies and an observational longitudinal study design. Collectively, the thesis supports a modulatory role for vitamin D in whole body and cellular bioenergetics and inflammation. Future studies could build on these findings; establishing a causal role for vitamin D in inflammation and energy metabolism.
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Alyami, A.; Soares, Mario; Sherriff, Jill; Mamo, John (2014)There is increasing interest in the extra-skeletal roles of vitamin D for health and well-being. Poor vitamin D status has been associated with obesity, cardiovascular disease, type 2 diabetes and mental health. Endothelial ...
Gorman, S.; Black, Lucinda; Feelisch, M.; Hart, P.; Weller, R. (2015)Liver inflammation contributes towards the pathology of non-alcoholic fatty liver disease (NAFLD). Here we discuss how skin exposure to sunlight may suppress liver inflammation and the severity of NAFLD. Following exposure ...
Calton, E.; Keane, Kevin; Soares, Mario (2015)Purpose of review The extraskeletal health benefits of vitamin D still need scientific endorsement. Obesity and related chronic diseases are pathogenically linked by inflammation, which carries a considerable energetic ...