The potential regulatory role of Vitamin D in the bioenergetics of inflammation
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Purpose of review The extraskeletal health benefits of vitamin D still need scientific endorsement. Obesity and related chronic diseases are pathogenically linked by inflammation, which carries a considerable energetic cost. Recent techniques for the determination of the bioenergetic demand of inflammation, offer an avenue to cement the regulatory role of vitamin D in this process. Recent findings Nuclear vitamin D receptors may be translocated into mitochondria of certain cell types, opening up a pathway for direct action on cellular bioenergetics. Classical M1 (inflammatory)/M2(anti-inflammatory) phenotypes can vary with the clinical context. M2 macrophages do not always depend on oxidative metabolism/fatty acid oxidation. Newer methodologies offer real-time bioenergetic measurements that can be used as an index of metabolic health. Summary Vitamin D may prove to be a therapeutic agent for inflammation of chronic disease and understanding its role in cellular bioenergetics may offer a diagnostic/prognostic indicator of its action.
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Winter to summer change in vitamin D status reduces systemic inflammation and bioenergetic activity of human peripheral blood mononuclear cellsCalton, E.; Keane, Kevin; Raizel, R.; Rowlands, J.; Soares, Mario; Newsholme, Philip (2017)Background: Vitamin D status [25(OH)D] has recently been reported to be associated with altered cellular bioenergetic profiles of peripheral blood mononuclear cells (PBMCs). No study has tracked the seasonal variation of ...
Calton, Emily Kathleen (2017)This thesis investigates the role of vitamin D metabolites 1,25-dihydroxyvitamin D and 25-hydroxyvitamin D in human bioenergetics and inflammation. The evidence presented comes from a narrative review, two systematic ...
Prevailing vitamin D status influences mitochondrial and glycolytic bioenergetics in peripheral blood mononuclear cells obtained from adultsCalton, Emily; Keane, Kevin; Soares, Mario; Rowlands, Jordan; Newsholme, Philip (2016)© 2016 The Authors. Background Circulating peripheral blood mononuclear cells (PBMCs) are exposed to metabolic and immunological stimuli that influence their functionality. We hypothesized that prevailing vitamin D status ...