Show simple item record

dc.contributor.authorTakechi, Ryu
dc.contributor.authorPallebage-Gamarallage, Menuka
dc.contributor.authorLam, Virginie
dc.contributor.authorGiles, Corey
dc.contributor.authorMamo, John
dc.identifier.citationTakechi, R. and Pallebage-Gamarallage, M. and Lam, V. and Giles, C. and Mamo, J. 2014. Long-term probucol therapy continues to suppress markers of neurovascular inflammation in a dietary induced model of cerebral capillary dysfunction. Lipids in Health and Disease. 13: Article ID 91.

Background: Probucol has been shown to prevent cerebral capillary disturbances characterized by blood-to-brain extravasation of plasma derived proteins and neurovascular inflammation in mice maintained on western-styled diets for 12 weeks. However the effect of probucol on capillary integrity in aging models with capillary dysfunction is not known. Methods: Wild-type C57BL6 mice were randomized to a low-fat (LF); saturated-fat (SFA); or SFA + Probucol diet for up to12 months of intervention. Results: Mice fed the LF diet had substantially greater parenchymal abundance of plasma derived IgG and apo B lipoproteins at 12 months, compared to LF mice at 3 months of intervention. Markers of neurovascular inflammation were also greater at 12 months in LF fed mice compared to LF mice at 3 months. The SFA diet exacerbated the aging induced parenchymal abundance of IgG and of apo B lipoproteins and neurovascular inflammation at 12 months. The SFA effects were associated with increased production of intestinal lipoprotein amyloid-ß (Aß). The co-provision of probucol with the SFA completely abolished heightened inflammation at 12 months. Probucol attenuated SFA-induced capillary permeability but had only a modest inhibitory effect on parenchymal retention of apoB lipoproteins. The improvements in markers of inflammation and capillary integrity because of probucol correlated with enterocytic genesis of chylomicron Aß. Conclusion: In this long-term feeding study, probucol profoundly suppressed dietary SFA induced disturbances in capillary integrity but had a more modest effect on age-associated changes.

dc.publisherBioMed Central Ltd.
dc.subjectApolipoprotein B
dc.subjectBrain capillaries
dc.subjectSaturated fatty acids
dc.subjectBlood–brain barrier
dc.titleLong-term probucol therapy continues to suppress markers of neurovascular inflammation in a dietary induced model of cerebral capillary dysfunction
dc.typeJournal Article
dcterms.source.titleLipids in Health and Disease

This article is published under the Open Access publishing model and distributed under the terms of the Creative Commons Attribution License Please refer to the licence to obtain terms for any further reuse or distribution of this work.

curtin.accessStatusOpen access

Files in this item


This item appears in the following Collection(s)

Show simple item record