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    The applied biochemistry of PEDF and implications for tissue homeostasis

    Access Status
    Fulltext not available
    Authors
    Broadhead, M.
    Becerra, S.
    Choong, P.
    Dass, Crispin
    Date
    2010
    Type
    Journal Article
    
    Metadata
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    Citation
    Broadhead, M. and Becerra, S. and Choong, P. and Dass, C. 2010. The applied biochemistry of PEDF and implications for tissue homeostasis. Growth Factors. 28 (4): pp. 280-285.
    Source Title
    Growth Factors
    DOI
    10.3109/08977191003604513
    Additional URLs
    http://informahealthcare.com/journal/grf
    ISSN
    0897-7194
    URI
    http://hdl.handle.net/20.500.11937/5775
    Collection
    • Curtin Research Publications
    Abstract

    Pigment epithelium-derived factor (PEDF) is an endogenously produced glycoprotein with a spectrum of biological roles across diverse pathologies. Recent research has focused on the biochemical properties of PEDF and its associated receptors. This review discusses the recent developments in PEDF biochemistry and how this new knowledge will help progress our understanding of PEDF as a molecular mediator for anti-angiogenesis and-tumorigenesis. Additionally, pathophysiological roles for PEDF in healing and tissue homeostasis are being revealed and our enhanced understanding of the interactions between PEDF and its receptors may yet prove useful in propelling PEDF towards clinical application.

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