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    Assessment of Cognition and Personality as Potential Endophenotypes in the Western Australian Family Study of Schizophrenia.

    Access Status
    Fulltext not available
    Authors
    McCarthy, N.
    Badcock, J.
    Clark, M.
    Knowles, E.
    Cadby, G.
    Melton, Phillip
    Morgan, V.
    Blangero, J.
    Moses, E.
    Glahn, D.
    Jablensky, A.
    Date
    2017
    Type
    Journal Article
    
    Metadata
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    Citation
    McCarthy, N. and Badcock, J. and Clark, M. and Knowles, E. and Cadby, G. and Melton, P. and Morgan, V. et al. 2017. Assessment of Cognition and Personality as Potential Endophenotypes in the Western Australian Family Study of Schizophrenia.. Schizophrenia Bulletin.
    Source Title
    Schizophrenia Bulletin
    DOI
    10.1093/schbul/sbx141
    ISSN
    1745-1701
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/58096
    Collection
    • Curtin Research Publications
    Abstract

    Phenotypic heterogeneity is a major barrier to understanding the genetic architecture underlying schizophrenia. Incorporating endophenotypes is one way to reduce heterogeneity and facilitate more powerful genetic analysis. Candidate endophenotypes require systematic assessment against endophenotype criteria, and a ranking of their potential utility for genetic analysis. In this study we assess 20 cognitive and personality measures in a sample of 127 families with at least 2 cases of schizophrenia per family (n = 535) plus a set of 30 control families (n = 121) against 4 endophenotype criteria: (a) be associated with the illness but not be a part of its diagnosis, (b) be heritable, (c) co-segregate with the illness in families, and (d) be found in unaffected relatives at a higher rate than in the general population. The endophenotype ranking score (endophenotype ranking variable [ERV]) was used to rank candidate endophenotypes based on their heritability and genetic correlation with schizophrenia. Finally, we used factor analysis to explore latent factors underlying the cognitive and personality measures. Evidence for personality measures as endophenotypes was at least equivalent to that of the cognitive measures. Factor analysis indicated that personality and cognitive traits contribute to independent latent dimensions. The results suggest for this first time that a number of cognitive and personality measures are independent and informative endophenotypes. Use of these endophenotypes in genetic studies will likely improve power and facilitate novel aetiological insights.

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