Antibody and B-cell responses may control circulating lipopolysaccharide in patients with HIV infection
|dc.identifier.citation||Lim, A. and Amini, A. and D'Orsogna, L. and Rajasuriar, R. and Kramski, M. and Lewin, S. and Purcell, D. et al. 2011. Antibody and B-cell responses may control circulating lipopolysaccharide in patients with HIV infection. AIDS. 25 (11): pp. 1379-1383.|
Objectives: To examine the relationship between plasma markers of microbial translocation and antibodies to lipopolysaccharide (LPS) and circulating memory B cells in patients with HIV infection. Design: Cross-sectional study in antiretroviral therapy (ART)-naive (n=23) and ART-treated (n=27) HIV patients. Methods: Antibodies to LPS and immunoglobulins, assayed in stored serum, and matched memory B-cell counts were correlated with levels of LPS and bacterial 16S ribosome DNA (16S rDNA), assayed in stored plasma. Results: In ART-naive patients, plasma LPS levels correlated inversely with serum levels of IgG and IgA antibodies to LPS (P=0.03 and 0.006, respectively), serum levels of IgA anti-LPS correlated with total IgA (P<0.0001) and levels of IgG anti-LPS correlated with IgM memory B-cell counts (P=0.025). In ART-treated patients, plasma LPS levels were not related to levels of LPS antibodies, but were related to CD4 T-cell and switched memory B-cell counts. There were no correlations with plasma levels of 16S rDNA. Conclusion: Plasma LPS levels were associated with antibody and possibly B-cell responses to LPS in ART-naive HIV patients, whereas they were associated with the degree of immune reconstitution in ART-treated patients. © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.
|dc.title||Antibody and B-cell responses may control circulating lipopolysaccharide in patients with HIV infection|
|curtin.department||School of Biomedical Sciences|
|curtin.accessStatus||Open access via publisher|
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